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10.1371/journal.pone.0180143 http://scihub22266oqcxt.onion/10.1371/journal.pone.0180143 C5501455!5501455 !28686604     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28686604 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2017 ; 12 (7 ): e0180143 Nephropedia Template TP {{tp|p=28686604 |t=2017. Boosting efferocytosis in alveolar space using BCG vaccine to protect host against influenza pneumonia |pdf=|usr=}}{{28686604 }} gab.com Text Boosting efferocytosis in alveolar space using BCG vaccine to protect host against influenza pneumonia JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28686604 #FOAvip Efferocytosis by alveolar phagocytes (APs) is pivotal in maintenance of lung homeostasis. Increased efferocytosis by APs results in protection against lethal acute lung injury due to pulmonary infections whereas defective efferocytosis by APs results in chronic lung inflammation. In this report, we show that pulmonary delivery of Bacillus Calmette-Guerin (BCG) significantly enhances efferocytosis by APs. Increased efferocytosis by APs maintains lung homeostasis and protects mice against lethal influenza pneumonia. Intranasally treated wild type C57Bl/6 (WT) mice with BCG showed significant increase in APs efferocytosis in vivo compared to their PBS-treated counterparts. All BCG-treated WT mice survived lethal influenza A virus (IAV) infection whereas all PBS-treated mice succumbed. BCG-induced resistance was abrogated by depleting AP prior to IAV infection. BCG treatment increased uptake, and digestion/removal of apoptotic cells by APs. BCG significantly increased the expression of TIM4 on APs and increased expression of Rab5 and Rab7. We demonstrated that increased efferocytosis by APs through pulmonary delivery of BCG initiated rapid clearance of apoptotic cells from the alveolar space, maintained lung homeostasis, reduced inflammation and protected host against lethal IAV pneumonia. Twit Text FOAVip Boosting efferocytosis in alveolar space using BCG vaccine to protect host against influenza pneumonia ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28686604 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28686604 #FOAvip English Wikipedia <ref>{{Cite pmid|28686604 }}</ref> Boosting efferocytosis in alveolar space using BCG vaccine to protect host against influenza pneumonia #MMPMID28686604 Mukherjee S ; Subramaniam R ; Chen H ; Smith A ; Keshava S ; Shams H PLoS One 2017[]; 12 (7 ): e0180143 PMID28686604 show ga Efferocytosis by alveolar phagocytes (APs) is pivotal in maintenance of lung homeostasis. Increased efferocytosis by APs results in protection against lethal acute lung injury due to pulmonary infections whereas defective efferocytosis by APs results in chronic lung inflammation. In this report, we show that pulmonary delivery of Bacillus Calmette-Guerin (BCG) significantly enhances efferocytosis by APs. Increased efferocytosis by APs maintains lung homeostasis and protects mice against lethal influenza pneumonia. Intranasally treated wild type C57Bl/6 (WT) mice with BCG showed significant increase in APs efferocytosis in vivo compared to their PBS-treated counterparts. All BCG-treated WT mice survived lethal influenza A virus (IAV) infection whereas all PBS-treated mice succumbed. BCG-induced resistance was abrogated by depleting AP prior to IAV infection. BCG treatment increased uptake, and digestion/removal of apoptotic cells by APs. BCG significantly increased the expression of TIM4 on APs and increased expression of Rab5 and Rab7. We demonstrated that increased efferocytosis by APs through pulmonary delivery of BCG initiated rapid clearance of apoptotic cells from the alveolar space, maintained lung homeostasis, reduced inflammation and protected host against lethal IAV pneumonia. |Animals [MESH] |BCG Vaccine/*administration & dosage [MESH] |Disease Models, Animal [MESH] |Humans [MESH] |Inflammation/complications/*drug therapy/prevention & control/virology [MESH] |Influenza A virus/drug effects/pathogenicity [MESH] |Influenza, Human/complications/*drug therapy/prevention & control/virology [MESH] |Lung/drug effects/pathology [MESH] |Macrophages, Alveolar/drug effects/pathology [MESH] |Mice [MESH] |Phagocytes/drug effects/pathology [MESH] |Phagocytosis/drug effects [MESH]Boosting efferocytosis in alveolar space using BCG vaccine to protect (epmc).pdf DeepDyve Pubget Overpricing