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2018 ; 4
(ä): 14
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Improving the efficiency of trials using innovative pilot designs: the next phase
in the conduct and reporting of pilot and feasibility studies
#MMPMID28694993
Thabane L
; Lancaster G
Pilot Feasibility Stud
2018[]; 4
(ä): 14
PMID28694993
show ga
With continuously increasing costs of conducting trials, use of innovative
approaches-such as pragmatic trials, registry-based randomised trials, adaptive
trials, personalised medicine trials, platform trials, and basket trials-to the
design and conduct of clinical trials has been advocated as one of the most
promising solutions. In this editorial, we propose that the next wave of
feasibility or pilot studies should focus on assessing the feasibility of trials
using these designs, which we see as an imperative in order to unleash their
potential to reduce trial costs and accelerate the drug development process and
the search for best treatments, so that the right treatments can be delivered as
soon as possible to the right patients.