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10.1186/s12882-017-0644-0 http://scihub22266oqcxt.onion/10.1186/s12882-017-0644-0 C5501341!5501341 !28683788     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28683788 &cmd=llinks): Failed to open stream: HTTP request failed! 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Successful treatment of a patient with refractory nephrotic syndrome with PCSK9 inhibitors: a case report |pdf=|usr=}}{{28683788 }} gab.com Text Successful treatment of a patient with refractory nephrotic syndrome with PCSK9 inhibitors: a case report JO: BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=28683788 #FOAvip BACKGROUND: The proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor evolocumab is a low-density lipoprotein (LDL)-lowering drug with a new mechanism, which is currently available in Japan. Here, for the first time, we report the successful use of the PCSK9 inhibitor in a patient with refractory nephrotic syndrome. CASE PRESENTATION: A 61-year-old woman was diagnosed with minimal change-type nephrotic syndrome in October 2012. She received prednisolone (PSL) and cyclosporin A (CyA), but she experienced several cycles of relapse and remission and was hospitalized in May 2016 due to relapse. However, in spite of steroid pulse therapy and adrenocorticotropic hormone (ACTH) administration, her urinary protein level did not improve. We started her on evolocumab with the expectation of equivalent LDL-lowering effects as seen with LDL apheresis. After that, the LDL cholesterol level and UP/UC were concomitantly decreased, and the serum albumin was increased. This was maintained even when we reduced the PSL dose. This suggests that evolocumab clinically improves the nephrotic condition. CONCLUSION: No other report has described the use of evolocumab for nephrotic syndrome (NS) or its effect on similar nephrotic conditions. We believe that the findings presented here are unique and may be beneficial when treating similar cases. Twit Text FOAVip Successful treatment of a patient with refractory nephrotic syndrome with PCSK9 inhibitors: a case report ????BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=28683788 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28683788 #FOAvip English Wikipedia <ref>{{Cite pmid|28683788 }}</ref> Successful treatment of a patient with refractory nephrotic syndrome with PCSK9 inhibitors: a case report #MMPMID28683788 Awanami Y ; Fukuda M ; Nonaka Y ; Takashima T ; Matsumoto K ; Yamasaki M ; Miyazono M ; Ikeda Y BMC Nephrol 2017[Jul]; 18 (1 ): 221 PMID28683788 show ga BACKGROUND: The proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor evolocumab is a low-density lipoprotein (LDL)-lowering drug with a new mechanism, which is currently available in Japan. Here, for the first time, we report the successful use of the PCSK9 inhibitor in a patient with refractory nephrotic syndrome. CASE PRESENTATION: A 61-year-old woman was diagnosed with minimal change-type nephrotic syndrome in October 2012. She received prednisolone (PSL) and cyclosporin A (CyA), but she experienced several cycles of relapse and remission and was hospitalized in May 2016 due to relapse. However, in spite of steroid pulse therapy and adrenocorticotropic hormone (ACTH) administration, her urinary protein level did not improve. We started her on evolocumab with the expectation of equivalent LDL-lowering effects as seen with LDL apheresis. After that, the LDL cholesterol level and UP/UC were concomitantly decreased, and the serum albumin was increased. This was maintained even when we reduced the PSL dose. This suggests that evolocumab clinically improves the nephrotic condition. CONCLUSION: No other report has described the use of evolocumab for nephrotic syndrome (NS) or its effect on similar nephrotic conditions. We believe that the findings presented here are unique and may be beneficial when treating similar cases. |*PCSK9 Inhibitors [MESH] |Antibodies, Monoclonal, Humanized [MESH] |Antibodies, Monoclonal/*administration & dosage [MESH] |Cyclosporine/administration & dosage [MESH] |Female [MESH] |Humans [MESH] |Middle Aged [MESH] |Nephrotic Syndrome/*diagnosis/*drug therapy [MESH] |Prednisolone/administration & dosage [MESH]Successful treatment of a patient with refractory nephrotic syndrome w(epmc).pdf DeepDyve Pubget Overpricing