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10.1101/sqb.2016.81.031120 http://scihub22266oqcxt.onion/10.1101/sqb.2016.81.031120 C5501288!5501288!28389596     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cold+Spring+Harb+Symp+Quant+Biol 2016 ; 81 (ä): 269-74 Nephropedia Template TP {{tp|p=28389596|t=2016. Single-Cell Analysis of Circulating Tumor Cells as a Window into Tumor Heterogeneity |pdf=|usr=}}{{28389596}} gab.com Text Single-Cell Analysis of Circulating Tumor Cells as a Window into Tumor Heterogeneity JO: Cold Spring Harb Symp Quant Biol http://www.kidney.de/pget.php?&tw=1&pmid=28389596 #FOAvip Recent advances in microfluidic approaches have enabled the efficient isolation and detailed molecular characterization of circulating tumor cells (CTCs) in the peripheral blood of patients with cancer. Single-cell molecular analyses of CTCs reveal a tremendous degree of intracellular heterogeneity in CTC populations, reflective of heterogeneity across different patients as well as the underlying heterogeneity of tumors within each individual patient. These studies have enabled the identification of heterogeneous drug resistance mechanisms that can coexist in treatment refractory tumors. CTC analyses also enable serial noninvasive monitoring in patients and can capture the emergence of tumor heterogeneity over time, whether due to tumor evolution through genetic instability or through cellular plasticity. The presence and extent of intratumoral heterogeneity as revealed through the study of CTCs have important clinical implications for understanding and predicting the development of treatment resistance in a variety of solid tumors and for formulating appropriate therapeutic strategies in the effective treatment of cancer. Twit Text FOAVip Single-Cell Analysis of Circulating Tumor Cells as a Window into Tumor Heterogeneity ????Cold Spring Harb Symp Quant Biol http://www.kidney.de/pget.php?&tw=1&pmid=28389596 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28389596 #FOAvip English Wikipedia <ref>{{Cite pmid|28389596}}</ref> Single-Cell Analysis of Circulating Tumor Cells as a Window into Tumor Heterogeneity #MMPMID28389596 Miyamoto DT; Ting DT; Toner M; Maheswaran S; Haber DA Cold Spring Harb Symp Quant Biol 2016[]; 81 (ä): 269-74 PMID28389596show ga Recent advances in microfluidic approaches have enabled the efficient isolation and detailed molecular characterization of circulating tumor cells (CTCs) in the peripheral blood of patients with cancer. Single-cell molecular analyses of CTCs reveal a tremendous degree of intracellular heterogeneity in CTC populations, reflective of heterogeneity across different patients as well as the underlying heterogeneity of tumors within each individual patient. These studies have enabled the identification of heterogeneous drug resistance mechanisms that can coexist in treatment refractory tumors. CTC analyses also enable serial noninvasive monitoring in patients and can capture the emergence of tumor heterogeneity over time, whether due to tumor evolution through genetic instability or through cellular plasticity. The presence and extent of intratumoral heterogeneity as revealed through the study of CTCs have important clinical implications for understanding and predicting the development of treatment resistance in a variety of solid tumors and for formulating appropriate therapeutic strategies in the effective treatment of cancer. äSingle-Cell Analysis of Circulating Tumor Cells as a Window into Tumor(epmc).pdf DeepDyve Pubget Overpricing