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10.1161/ATVBAHA.117.309539 http://scihub22266oqcxt.onion/10.1161/ATVBAHA.117.309539 C5501287!5501287!28495930     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28495930&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arterioscler+Thromb+Vasc+Biol 2017 ; 37 (7): 1332-8 Nephropedia Template TP {{tp|p=28495930|t=2017. ADAMTS13 retards progression of diabetic nephropathy by inhibiting intrarenal thrombosis in mice |pdf=|usr=}}{{28495930}} gab.com Text ADAMTS13 retards progression of diabetic nephropathy by inhibiting intrarenal thrombosis in mice JO: Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=28495930 #FOAvip Objective: ADAMTS13 (A Disintegrin And Metalloprotease with Thrombospondin type I repeats-13) prevents microvascular thrombosis by cleaving prothrombogenic ultra-large von Willebrand factor (ULVWF) multimers. Clinical studies have found association between reduced ADAMTS13 specific activity, ULVWF multimers and thrombotic angiopathy in patients with diabetic nephropathy. It remains unknown, however, whether ADAMTS13 deficiency or ULVWF multimers have a causative effect in diabetic nephropathy. Approach and Results: The extent of renal injury was evaluated in wild-type (WT), Adamts13?/? and Adamts13?/?Vwf?/? mice after 26 weeks of streptozotocin-induced diabetic nephropathy. We found that WT diabetic mice exhibited low plasma ADAMTS13 specific activity and increased VWF levels (P<0.05 vs. WT-non diabetic mice). Adamts13?/? diabetic mice exhibited deterioration of kidney function (increased albuminuria, plasma creatinine and urea; P<0.05 versus WT diabetic mice), independent of hyperglycemia and hypertension. Deterioration of kidney function in Adamts13?/? diabetic mice was concomitant with aggravated intrarenal thrombosis (assessed by plasminogen activator inhibitor (PAI-1), VWF, fibrin(ogen) and CD41 positive microthrombi), increased mesangial cell expansion and extracellular matrix deposition (P<0.05 versus WT diabetic mice). Genetic deletion of VWF in Adamts13?/? diabetic mice improved kidney function, inhibited intrarenal thrombosis and alleviated histological changes in glomeruli, suggesting that exacerbation of diabetic nephropathy in the setting of ADAMTS13 deficiency is VWF-dependent. Conclusions: ADAMTS13 retards progression of diabetic nephropathy, most likely by inhibiting VWF-dependent intrarenal thrombosis. Alteration in ADAMTS13-VWF balance may be one of the key pathophysiological mechanisms of thrombotic angiopathy in diabetes. Twit Text FOAVip ADAMTS13 retards progression of diabetic nephropathy by inhibiting intrarenal thrombosis in mice ????Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=28495930 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28495930 #FOAvip English Wikipedia <ref>{{Cite pmid|28495930}}</ref> ADAMTS13 retards progression of diabetic nephropathy by inhibiting intrarenal thrombosis in mice #MMPMID28495930 Dhanesha N; Doddapattar P; Chorawala MR; Nayak MK; Kokame K; Staber JM; Lentz SR; Chauhan AK Arterioscler Thromb Vasc Biol 2017[Jul]; 37 (7): 1332-8 PMID28495930show ga Objective: ADAMTS13 (A Disintegrin And Metalloprotease with Thrombospondin type I repeats-13) prevents microvascular thrombosis by cleaving prothrombogenic ultra-large von Willebrand factor (ULVWF) multimers. Clinical studies have found association between reduced ADAMTS13 specific activity, ULVWF multimers and thrombotic angiopathy in patients with diabetic nephropathy. It remains unknown, however, whether ADAMTS13 deficiency or ULVWF multimers have a causative effect in diabetic nephropathy. Approach and Results: The extent of renal injury was evaluated in wild-type (WT), Adamts13?/? and Adamts13?/?Vwf?/? mice after 26 weeks of streptozotocin-induced diabetic nephropathy. We found that WT diabetic mice exhibited low plasma ADAMTS13 specific activity and increased VWF levels (P<0.05 vs. WT-non diabetic mice). Adamts13?/? diabetic mice exhibited deterioration of kidney function (increased albuminuria, plasma creatinine and urea; P<0.05 versus WT diabetic mice), independent of hyperglycemia and hypertension. Deterioration of kidney function in Adamts13?/? diabetic mice was concomitant with aggravated intrarenal thrombosis (assessed by plasminogen activator inhibitor (PAI-1), VWF, fibrin(ogen) and CD41 positive microthrombi), increased mesangial cell expansion and extracellular matrix deposition (P<0.05 versus WT diabetic mice). Genetic deletion of VWF in Adamts13?/? diabetic mice improved kidney function, inhibited intrarenal thrombosis and alleviated histological changes in glomeruli, suggesting that exacerbation of diabetic nephropathy in the setting of ADAMTS13 deficiency is VWF-dependent. Conclusions: ADAMTS13 retards progression of diabetic nephropathy, most likely by inhibiting VWF-dependent intrarenal thrombosis. Alteration in ADAMTS13-VWF balance may be one of the key pathophysiological mechanisms of thrombotic angiopathy in diabetes. äADAMTS13 retards progression of diabetic nephropathy by inhibiting int(epmc).pdf DeepDyve Pubget Overpricing