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2017 ; 18
(1
): 222
Nephropedia Template TP
gab.com Text
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English Wikipedia
CRRTnet: a prospective, multi-national, observational study of continuous renal
replacement therapy practices
#MMPMID28683729
Heung M
; Bagshaw SM
; House AA
; Juncos LA
; Piazza R
; Goldstein SL
BMC Nephrol
2017[Jul]; 18
(1
): 222
PMID28683729
show ga
BACKGROUND: Continuous renal replacement therapy (CRRT) is the recommended
modality of dialysis for critically ill patients with hemodynamic instability.
Yet there remains significant variability in how CRRT is prescribed and
delivered, and limited evidence-basis to guide practice. METHODS: This is a
prospective, multi-center observational study of patients undergoing CRRT.
Initial enrollment phase will occur at 4 academic medical centers in North
America over 5 years, with a target enrollment of 2000 patients. All adult
patients (18-89 years of age) receiving CRRT will be eligible for inclusion;
patients who undergo CRRT for less than 24 h will be excluded from analysis. Data
collection will include patient characteristics at baseline and at time of CRRT
initiation; details of CRRT prescription and delivery, including
machine-generated treatment data; and patient outcomes. DISCUSSION: The goal of
this study is to establish a large comprehensive registry of critically ill
adults receiving CRRT. Specific aims include describing variations in CRRT
prescription and delivery across quality domains; validating quality measures for
CRRT care by correlating processes and outcomes; and establishing a large
registry for use in quality improvement and benchmarking efforts. For initial
analyses, some particular areas of interest are anticoagulation protocols;
approach to fluid overload; CRRT-related workload; and patient safety. TRIAL
REGISTRATION: Registered on ClinicalTrials.gov 1/10/2014: NCT02034448.