Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3892/ijmm.2017.3036 http://scihub22266oqcxt.onion/10.3892/ijmm.2017.3036 C5500920!5500920 !28656226     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28656226 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Med 2017 ; 40 (2 ): 271-280 Nephropedia Template TP {{tp|p=28656226 |t=2017. The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review) |pdf=|usr=}}{{28656226 }} gab.com Text The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review) JO: Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28656226 #FOAvip Protein phosphorylation is an impo-rtant cellular regulatory mechanism as many enzymes and receptors are activated/deactivated by phosphorylation and dephosphorylation events, by means of kinases and phosph-atases. In particular, the protein kinases are responsible for cellular transduction signaling and their hyperactivity, malfunction or overexpression can be found in several diseases, mostly tumors. Therefore, it is evident that the use of kinase inhibitors can be valuable for the treatment of cancer. In this review, we discuss the mechanism of action of phosphorylation, with particular attention to the importance of phosphorylation under physiological and pathological conditions. We also discuss the possibility of using kinase inhibitors in the treatment of tumors. Twit Text FOAVip The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review) ????Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28656226 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28656226 #FOAvip English Wikipedia <ref>{{Cite pmid|28656226 }}</ref> The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review) #MMPMID28656226 Ardito F ; Giuliani M ; Perrone D ; Troiano G ; Lo Muzio L Int J Mol Med 2017[Aug]; 40 (2 ): 271-280 PMID28656226 show ga Protein phosphorylation is an impo-rtant cellular regulatory mechanism as many enzymes and receptors are activated/deactivated by phosphorylation and dephosphorylation events, by means of kinases and phosph-atases. In particular, the protein kinases are responsible for cellular transduction signaling and their hyperactivity, malfunction or overexpression can be found in several diseases, mostly tumors. Therefore, it is evident that the use of kinase inhibitors can be valuable for the treatment of cancer. In this review, we discuss the mechanism of action of phosphorylation, with particular attention to the importance of phosphorylation under physiological and pathological conditions. We also discuss the possibility of using kinase inhibitors in the treatment of tumors. |Animals [MESH] |Humans [MESH] |Molecular Targeted Therapy/*methods [MESH] |Neoplasms/*drug therapy/enzymology [MESH] |Phosphoric Monoester Hydrolases/metabolism [MESH] |Phosphorylation/*drug effects [MESH] |Protein Kinase Inhibitors/pharmacology/*therapeutic use [MESH] |Protein Kinases/*metabolism [MESH]The crucial role of protein phosphorylation in cell signaling and its (epmc).pdf DeepDyve Pubget Overpricing