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Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Expert+Opin+Investig+Drugs 2008 ; 17 (4): 451-67 Nephropedia Template TP
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NOVEL TARGETS AND NEW POTENTIAL: DEVELOPMENTS IN THE TREATMENT OF INFLAMMATION IN CHRONIC KIDNEY DISEASE #MMPMID18363512
Kovesdy CP; Kalantar-Zadeh K
Expert Opin Investig Drugs 2008[Apr]; 17 (4): 451-67 PMID18363512show ga
Background: Patients with chronic kidney disease (CKD) of all stages experience extremely high mortality, with cardiovascular causes accounting for about half of all their deaths. Traditional risk factors such as hypertension, hypercholesterolemia and diabetes mellitus cannot explain the excessively high cardiovascular mortality in CKD. Chronic inflammation is one of the novel risk factors that appear to contribute to the increased mortality seen in patients with CKD. Therapeutic interventions targeting chronic inflammation in CKD may lead to improved outcomes. Objectives: To describe the role of inflammation in CKD and to review antiinflammatory pharmacologic therapies that could have a role in its therapy. Methods: Review of the literature and expert opinion. Results/Conclusion: Inflammation is a common and significant problem in CKD. There are currently no approved pharmacologic antiinflammatory therapies in CKD, but several agents are being studied in early clinical trials, while others could become viable alternatives in the future.