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10.1517/13543784.17.4.451 http://scihub22266oqcxt.onion/10.1517/13543784.17.4.451 C5500838!5500838 !18363512     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\18363512 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Expert+Opin+Investig+Drugs 2008 ; 17 (4 ): 451-67 Nephropedia Template TP {{tp|p=18363512 |t=2008. Novel targets and new potential: developments in the treatment of inflammation in chronic kidney disease |pdf=|usr=}}{{18363512 }} gab.com Text Novel targets and new potential: developments in the treatment of inflammation in chronic kidney disease JO: Expert Opin Investig Drugs http://www.kidney.de/pget.php?&tw=1&pmid=18363512 #FOAvip BACKGROUND: Patients with chronic kidney disease (CKD) of all stages experience extremely high mortality, with cardiovascular causes accounting for about half of all their deaths. Traditional risk factors such as hypertension, hypercholesterolemia and diabetes mellitus cannot explain the excessively high cardiovascular mortality in CKD. Chronic inflammation is one of the novel risk factors that appear to contribute to the increased mortality seen in patients with CKD. Therapeutic interventions targeting chronic inflammation in CKD may lead to improved outcomes. OBJECTIVES: To describe the role of inflammation in CKD and to review anti-inflammatory pharmacologic therapies that could have a role in its therapy. METHODS: A review of the literature was carried out and expert opinion expressed. RESULTS/CONCLUSION: Inflammation is a common and significant problem in CKD. There are currently no approved pharmacologic anti-inflammatory therapies in CKD but several agents are being studied in early clinical trials, while others could become viable alternatives in the future. Twit Text FOAVip Novel targets and new potential: developments in the treatment of inflammation in chronic kidney disease ????Expert Opin Investig Drugs http://www.kidney.de/pget.php?&tw=1&pmid=18363512 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18363512 #FOAvip English Wikipedia <ref>{{Cite pmid|18363512 }}</ref> Novel targets and new potential: developments in the treatment of inflammation in chronic kidney disease #MMPMID18363512 Kovesdy CP ; Kalantar-Zadeh K Expert Opin Investig Drugs 2008[Apr]; 17 (4 ): 451-67 PMID18363512 show ga BACKGROUND: Patients with chronic kidney disease (CKD) of all stages experience extremely high mortality, with cardiovascular causes accounting for about half of all their deaths. Traditional risk factors such as hypertension, hypercholesterolemia and diabetes mellitus cannot explain the excessively high cardiovascular mortality in CKD. Chronic inflammation is one of the novel risk factors that appear to contribute to the increased mortality seen in patients with CKD. Therapeutic interventions targeting chronic inflammation in CKD may lead to improved outcomes. OBJECTIVES: To describe the role of inflammation in CKD and to review anti-inflammatory pharmacologic therapies that could have a role in its therapy. METHODS: A review of the literature was carried out and expert opinion expressed. RESULTS/CONCLUSION: Inflammation is a common and significant problem in CKD. There are currently no approved pharmacologic anti-inflammatory therapies in CKD but several agents are being studied in early clinical trials, while others could become viable alternatives in the future. |*Drug Design [MESH] |Anti-Inflammatory Agents/pharmacology/*therapeutic use [MESH] |B-Lymphocytes/drug effects [MESH] |Cardiovascular Diseases/*etiology/immunology/mortality/prevention & control [MESH] |Drugs, Investigational/pharmacology/*therapeutic use [MESH] |Humans [MESH] |Interleukin-1/antagonists & inhibitors [MESH] |Interleukin-15/antagonists & inhibitors [MESH] |Interleukin-18/antagonists & inhibitors [MESH] |Lymphocyte Activation/drug effects [MESH] |Nephritis/complications/*drug therapy/etiology/immunology/mortality [MESH] |Renal Insufficiency, Chronic/*complications/drug therapy/immunology/mortality [MESH] |Risk Factors [MESH] |Treatment Outcome [MESH]Novel targets and new potential: developments in the treatment of infl(epmc).pdf DeepDyve Pubget Overpricing