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10.1074/jbc.M116.752352 http://scihub22266oqcxt.onion/10.1074/jbc.M116.752352 C5500804!5500804 !28550085     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28550085 &cmd=llinks): Failed to open stream: HTTP request failed! 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Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells |pdf=|usr=}}{{28550085 }} gab.com Text Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28550085 #FOAvip Mesenchymal-to-epithelial transition (MET) and epithelial-to-mesenchymal transition (EMT) are important processes in kidney development. Failure to undergo MET during development leads to the initiation of Wilms tumor, whereas EMT contributes to the development of renal cell carcinomas (RCC). The role of calcium regulators in governing these processes is becoming evident. We demonstrated earlier that Na(+)/Ca(2+) exchanger 1 (NCX1), a major calcium exporter in renal epithelial cells, regulates epithelial cell motility. Here, we show for the first time that NCX1 mRNA and protein expression was down-regulated in Wilms tumor and RCC. Knockdown of NCX1 in Madin-Darby canine kidney cells induced fibroblastic morphology, increased intercellular junctional distance, and induced paracellular permeability, loss of apico-basal polarity in 3D cultures, and anchorage-independent growth, accompanied by expression of mesenchymal markers. We also provide evidence that NCX1 interacts with and anchors E-cadherin to the cell surface independent of NCX1 ion transport activity. Consistent with destabilization of E-cadherin, NCX1 knockdown cells showed an increase in ?-catenin nuclear localization, enhanced transcriptional activity, and up-regulation of downstream targets of the ?-catenin signaling pathway. Taken together, knockdown of NCX1 in Madin-Darby canine kidney cells alters epithelial morphology and characteristics by destabilization of E-cadherin and induction of ?-catenin signaling. Twit Text FOAVip Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28550085 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28550085 #FOAvip English Wikipedia <ref>{{Cite pmid|28550085 }}</ref> Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells #MMPMID28550085 Balasubramaniam SL ; Gopalakrishnapillai A ; Petrelli NJ ; Barwe SP J Biol Chem 2017[Jul]; 292 (27 ): 11388-11399 PMID28550085 show ga Mesenchymal-to-epithelial transition (MET) and epithelial-to-mesenchymal transition (EMT) are important processes in kidney development. Failure to undergo MET during development leads to the initiation of Wilms tumor, whereas EMT contributes to the development of renal cell carcinomas (RCC). The role of calcium regulators in governing these processes is becoming evident. We demonstrated earlier that Na(+)/Ca(2+) exchanger 1 (NCX1), a major calcium exporter in renal epithelial cells, regulates epithelial cell motility. Here, we show for the first time that NCX1 mRNA and protein expression was down-regulated in Wilms tumor and RCC. Knockdown of NCX1 in Madin-Darby canine kidney cells induced fibroblastic morphology, increased intercellular junctional distance, and induced paracellular permeability, loss of apico-basal polarity in 3D cultures, and anchorage-independent growth, accompanied by expression of mesenchymal markers. We also provide evidence that NCX1 interacts with and anchors E-cadherin to the cell surface independent of NCX1 ion transport activity. Consistent with destabilization of E-cadherin, NCX1 knockdown cells showed an increase in ?-catenin nuclear localization, enhanced transcriptional activity, and up-regulation of downstream targets of the ?-catenin signaling pathway. Taken together, knockdown of NCX1 in Madin-Darby canine kidney cells alters epithelial morphology and characteristics by destabilization of E-cadherin and induction of ?-catenin signaling. |*Epithelial-Mesenchymal Transition [MESH] |*Signal Transduction [MESH] |Animals [MESH] |Cadherins/genetics/metabolism [MESH] |Dogs [MESH] |Gene Knockdown Techniques [MESH] |Kidney/cytology/*metabolism [MESH] |Madin Darby Canine Kidney Cells [MESH] |Protein Stability [MESH] |Sodium-Calcium Exchanger/genetics/*metabolism [MESH]Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchy(epmc).pdf DeepDyve Pubget Overpricing