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2017 ; 7
(1
): 4836
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Serum D-dimer is a potential predictor for thromboembolism complications in
patients with renal biopsy
#MMPMID28684778
Tan X
; Chen G
; Liu Y
; Zhou L
; He L
; Liu D
; Liu Y
; Zhang F
; Li H
; Liu H
Sci Rep
2017[Jul]; 7
(1
): 4836
PMID28684778
show ga
Renal biopsy has been widely recommended in clinic to determine the histological
patterns of kidney disease. To prevent bleeding complications, patients should
routinely stop anticoagulants prior to renal biopsy. However, patients with
kidney disease are susceptible to thromboembolisms, particularly in those with
severe hypoalbuminemia. This study was designed to investigate the application of
serum D-dimer as a predictor for thrombotic events after renal biopsy. 400
consecutive native renal biopsies were prospectively included in this 2-month
follow-up study. The overall incidence of bleeding and thrombotic complication is
4%, including hematuria or large perinephric hematoma (2.5%, n?=?10) and
thrombotic complication (1.5%, n?=?6). Compared to low serum D-dimer
(<2.00??g/ml), subjects in the group of high serum D-dimer (?2.00??g/ml) were
more incline to develop thrombotic complications (9.1% versus 0.3%; RR, 30.33;
p?0.001). D-dimer correlated positively with age (r(s)?=?0.258, P?0.001).
Inverse correlations were found for albumin (r(s)?=?-0.339, P?0.001). Taken
together, patients with high serum D-dimer carry an increased risk of thrombotic
complications after renal biopsy. Our findings suggest that serum D-dimer can
serve as a potential predictor for thrombotic events in patients with kidney
disease. Further cautions should be given to these subjects.