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2017 ; 7
(1
): 4753
Nephropedia Template TP
gab.com Text
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English Wikipedia
Multiple fresh fecal microbiota transplants induces and maintains clinical
remission in Crohn s disease complicated with inflammatory mass
#MMPMID28684845
He Z
; Li P
; Zhu J
; Cui B
; Xu L
; Xiang J
; Zhang T
; Long C
; Huang G
; Ji G
; Nie Y
; Wu K
; Fan D
; Zhang F
Sci Rep
2017[Jul]; 7
(1
): 4753
PMID28684845
show ga
The ancient Chinese medical literature, as well as our prior clinical experience,
suggests that fecal microbiota transplantation (FMT) could treat the inflammatory
mass. We aimed to evaluate the efficacy and safety of multiple fresh FMTs for
Crohn's disease (CD) complicated with intraabdominal inflammatory mass. The
"one-hour FMT protocol" was followed in all patients. Twenty-five patients were
diagnosed with CD and related inflammatory mass by CT or MRI. All patients
received the initial FMT followed by repeated FMTs every 3 months. The primary
endpoint was clinical response (improvement and remission) and sustained clinical
remission at 12 months. Secondary endpoints were improvement in size of
phegmon/abscess based upon cross-sectional imaging and safety of FMT. 68.0%
(17/25) and 52.0% (13/25) of patients achieved clinical response and clinical
remission at 3 months post the initial FMT, respectively. The proportion of
patients at 6 months, 12 months and 18 months achieving sustained clinical
remission with sequential FMTs was 48.0% (12/25), 32.0% (8/25) and 22.7% (5/22),
respectively. 9.5% (2/21) of patients achieved radiological healing and 71.4%
(15/21) achieved radiological improvement. No severe adverse events related to
FMT were observed. This pragmatic study suggested that sequential fresh FMTs
might be a promising, safe and effective therapy to induce and maintain clinical
remission in CD with intraabdominal inflammatory mass.