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2017 ; 96
(26
): e7267
Nephropedia Template TP
gab.com Text
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English Wikipedia
Surgical outcome and etiologic heterogeneity of infants with biliary atresia who
received Kasai operation less than 60 days after birth: A retrospective study
#MMPMID28658122
Song Z
; Dong R
; Shen Z
; Chen G
; Yang Y
; Zheng S
Medicine (Baltimore)
2017[Jun]; 96
(26
): e7267
PMID28658122
show ga
This study aimed to analyze the impact of etiologic heterogeneity and operation
age on prognosis of infants with biliary atresia (BA) who received Kasai
operation prior to 60 days of age.From 2004 to 2010, 158 infants received Kasai
operation before turning 60 days old. According to Davenport 2012
classifications, 4 groups of BA were defined: cystic BA, syndrome BA, and
associated malformation, cytomegalovirus (CMV)-associated BA, and isolated BA.
Native (autologous) liver survival rates and incidence of cholangitis 2 years
after operation, as well as jaundice clearance rates 3 months after operation,
were recorded.Although infants who received the operation between 51 and 60 days
of age had a better jaundice clearance 3 months after operation and lower
incidence of cholangitis as compared with those under 40 or between 41 and 50
days of age, there was no significant difference in survival rates. Among types
of BA, infants with cystic BA had the best prognosis. In the syndrome BA and
associated malformations group, as well as CMV-associated group, infants who
received the operation early (<40 days of age) had a worse outcome as compared
with those who received the operation between 41 and 50 days or 51 and 60 days of
age.Both clinical etiologic heterogeneity and operation age may influence BA
prognosis.