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10.1002/eji.201646716 http://scihub22266oqcxt.onion/10.1002/eji.201646716 C5499671!5499671!28102541     free     free     free       Eur+J+Immunol 2017 ; 47 (3): 446-53 Nephropedia Template TP {{tp|p=28102541|t=2017. TGF-? regulation of T cells in multiple sclerosis |pdf=|usr=}}{{28102541}} gab.com Text TGF- regulation of T cells in multiple sclerosis JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28102541 #FOAvip Transforming growth factor-beta (TGF-?) is a pleiotrophic cytokine that has been shown to influence the differentiation and function of T cells. As such, the role that TGF-? plays in immune-mediated disease, such as multiple sclerosis (MS), has become a major area of investigation since CD4 T cells appear to be a major mediator of the autoimmunity. This review analysis the literature on the role that TGF-? plays in the generation and regulation of encephalitogenic T cells in experimental autoimmune encephalomyelitis, an animal model of MS, as well as T cells of MS patients. Since TGF-? plays a major role in the development and function of CD4 regulatory T cells, which are defective in MS patients, recent studies have found potential mechanisms to explain the basis for these regulatory T cell defects to establish a foundation for potentially modulating TGF-? signaling to restore normal T cell function in MS patients. Twit Text FOAVip TGF- regulation of T cells in multiple sclerosis ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28102541 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28102541 #FOAvip English Wikipedia <ref>{{Cite pmid|28102541}}</ref> TGF-? regulation of T cells in multiple sclerosis #MMPMID28102541 Lee PW; Severin ME; Lovett-Racke AE Eur J Immunol 2017[Mar]; 47 (3): 446-53 PMID28102541show ga Transforming growth factor-beta (TGF-?) is a pleiotrophic cytokine that has been shown to influence the differentiation and function of T cells. As such, the role that TGF-? plays in immune-mediated disease, such as multiple sclerosis (MS), has become a major area of investigation since CD4 T cells appear to be a major mediator of the autoimmunity. This review analysis the literature on the role that TGF-? plays in the generation and regulation of encephalitogenic T cells in experimental autoimmune encephalomyelitis, an animal model of MS, as well as T cells of MS patients. Since TGF-? plays a major role in the development and function of CD4 regulatory T cells, which are defective in MS patients, recent studies have found potential mechanisms to explain the basis for these regulatory T cell defects to establish a foundation for potentially modulating TGF-? signaling to restore normal T cell function in MS patients. äTGF-? regulation of T cells in multiple sclerosis (epmc).pdf DeepDyve Pubget Overpricing