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10.4062/biomolther.2016.003 http://scihub22266oqcxt.onion/10.4062/biomolther.2016.003 C5499621!5499621!28190316     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomol+Ther+(Seoul) 2017 ; 25 (4): 417-26 Nephropedia Template TP {{tp|p=28190316|t=2017. 4-O-Methylhonokiol Protects HaCaT Cells from TGF-?1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-? Signaling |pdf=|usr=}}{{28190316}} gab.com Text 4-O-Methylhonokiol Protects HaCaT Cells from TGF- 1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF- Signaling JO: Biomol Ther (Seoul) http://www.kidney.de/pget.php?&tw=1&pmid=28190316 #FOAvip 4-O-methylhonokiol, a neolignan compound from Magnolia Officinalis, has been reported to have various biological activities including hair growth promoting effect. However, although transforming growth factor-? (TGF-?) signal pathway has an essential role in the regression induction of hair growth, the effect of 4-O-methylhonokiol on the TGF-? signal pathway has not yet been elucidated. We thus examined the effect of 4-O-methylhonokiol on TGF-?-induced canonical and noncanonical pathways in HaCaT human keratinocytes. When HaCaT cells were pretreated with 4-O-methylhonokiol, TGF-?1-induced G1/G0 phase arrest and TGF-?1-induced p21 expression were decreased. Moreover, 4-O-methylhonokiol inhibited nuclear translocation of Smad2/3, Smad4 and Sp1 in TGF-?1-induced canonical pathway. We observed that ERK phosphorylation by TGF-?1 was significantly attenuated by treatment with 4-O-methylhonokiol. 4-O-methylhonokiol inhibited TGF-?1-induced reactive oxygen species (ROS) production and reduced the increase of NADPH oxidase 4 (NOX4) mRNA level in TGF-?1-induced noncanonical pathway. These results indicate that 4-O-methylhonokiol could inhibit TGF-?1-induced cell cycle arrest through inhibition of canonical and noncanonical pathways in human keratinocyte HaCaT cell and that 4-O-methylhonokiol might have protective action on TGF-?1-induced cell cycle arrest. Twit Text FOAVip 4-O-Methylhonokiol Protects HaCaT Cells from TGF- 1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF- Signaling ????Biomol Ther (Seoul) http://www.kidney.de/pget.php?&tw=1&pmid=28190316 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28190316 #FOAvip English Wikipedia <ref>{{Cite pmid|28190316}}</ref> 4-O-Methylhonokiol Protects HaCaT Cells from TGF-?1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-? Signaling #MMPMID28190316 Kim SC; Kang JI; Hyun JW; Kang JH; Koh YS; Kim YH; Kim KH; Ko JH; Yoo ES; Kang HK Biomol Ther (Seoul) 2017[Jul]; 25 (4): 417-26 PMID28190316show ga 4-O-methylhonokiol, a neolignan compound from Magnolia Officinalis, has been reported to have various biological activities including hair growth promoting effect. However, although transforming growth factor-? (TGF-?) signal pathway has an essential role in the regression induction of hair growth, the effect of 4-O-methylhonokiol on the TGF-? signal pathway has not yet been elucidated. We thus examined the effect of 4-O-methylhonokiol on TGF-?-induced canonical and noncanonical pathways in HaCaT human keratinocytes. When HaCaT cells were pretreated with 4-O-methylhonokiol, TGF-?1-induced G1/G0 phase arrest and TGF-?1-induced p21 expression were decreased. Moreover, 4-O-methylhonokiol inhibited nuclear translocation of Smad2/3, Smad4 and Sp1 in TGF-?1-induced canonical pathway. We observed that ERK phosphorylation by TGF-?1 was significantly attenuated by treatment with 4-O-methylhonokiol. 4-O-methylhonokiol inhibited TGF-?1-induced reactive oxygen species (ROS) production and reduced the increase of NADPH oxidase 4 (NOX4) mRNA level in TGF-?1-induced noncanonical pathway. These results indicate that 4-O-methylhonokiol could inhibit TGF-?1-induced cell cycle arrest through inhibition of canonical and noncanonical pathways in human keratinocyte HaCaT cell and that 4-O-methylhonokiol might have protective action on TGF-?1-induced cell cycle arrest. ä4-O-Methylhonokiol Protects HaCaT Cells from TGF-?1-Induced Cell Cycle(epmc).pdf DeepDyve Pubget Overpricing