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http://scihub22266oqcxt.onion/ C5499530!5499530!20545610     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Drug+Targets 2010 ; 11 (9): 1103-11 Nephropedia Template TP {{tp|p=20545610|t=2010. Hedgehog Signaling in the Normal and Neoplastic Mammary Gland |pdf=|usr=}}{{20545610}} gab.com Text Hedgehog Signaling in the Normal and Neoplastic Mammary Gland JO: Curr Drug Targets http://www.kidney.de/pget.php?&tw=1&pmid=20545610 #FOAvip The hedgehog signal transduction network is a critical regulator of metazoan development. Inappropriate activation of this network is implicated in several different cancers, including breast. Genetic evidence in mice as well as molecular biological studies in human cells clearly indicate that activated signaling can lead to mammary hyperplasia and, in some cases, tumor formation. However, the exact role(s) activated hedgehog signaling plays in the development or progression of breast cancer also remain unclear. In this chapter, we review recent data regarding the mechanism(s) by which the hedgehog network may signal in the mammary gland, as well as the data implicating activated signaling as a contributing factor to breast cancer development. Finally, we provide a brief update on the available hedgehog signaling inhibitors with respect to ongoing clinical trials, some of which will include locally advanced or metastatic breast cancers. Given the growing intensity with which the hedgehog signaling network is being studied in the normal and neoplastic mammary gland, a more complete understanding of this network should allow more effective targeting of its activities in breast cancer treatment or prevention. Twit Text FOAVip Hedgehog Signaling in the Normal and Neoplastic Mammary Gland ????Curr Drug Targets http://www.kidney.de/pget.php?&tw=1&pmid=20545610 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20545610 #FOAvip English Wikipedia <ref>{{Cite pmid|20545610}}</ref> Hedgehog Signaling in the Normal and Neoplastic Mammary Gland #MMPMID20545610 Visbal AP; Lewis MT Curr Drug Targets 2010[Sep]; 11 (9): 1103-11 PMID20545610show ga The hedgehog signal transduction network is a critical regulator of metazoan development. Inappropriate activation of this network is implicated in several different cancers, including breast. Genetic evidence in mice as well as molecular biological studies in human cells clearly indicate that activated signaling can lead to mammary hyperplasia and, in some cases, tumor formation. However, the exact role(s) activated hedgehog signaling plays in the development or progression of breast cancer also remain unclear. In this chapter, we review recent data regarding the mechanism(s) by which the hedgehog network may signal in the mammary gland, as well as the data implicating activated signaling as a contributing factor to breast cancer development. Finally, we provide a brief update on the available hedgehog signaling inhibitors with respect to ongoing clinical trials, some of which will include locally advanced or metastatic breast cancers. Given the growing intensity with which the hedgehog signaling network is being studied in the normal and neoplastic mammary gland, a more complete understanding of this network should allow more effective targeting of its activities in breast cancer treatment or prevention. äHedgehog Signaling in the Normal and Neoplastic Mammary Gland (epmc).pdf DeepDyve Pubget Overpricing