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10.1146/annurev-med-100415-022956 http://scihub22266oqcxt.onion/10.1146/annurev-med-100415-022956 C5499376!5499376 !28099082     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28099082 &cmd=llinks): Failed to open stream: HTTP request failed! 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Therapeutics Targeting Drivers of Thoracic Aortic Aneurysms and Acute Aortic Dissections: Insights from Predisposing Genes and Mouse Models |pdf=|usr=}}{{28099082 }} gab.com Text Therapeutics Targeting Drivers of Thoracic Aortic Aneurysms and Acute Aortic Dissections: Insights from Predisposing Genes and Mouse Models JO: Annu Rev Med http://www.kidney.de/pget.php?&tw=1&pmid=28099082 #FOAvip Thoracic aortic diseases, including aneurysms and dissections of the thoracic aorta, are a major cause of morbidity and mortality. Risk factors for thoracic aortic disease include increased hemodynamic forces on the ascending aorta, typically due to poorly controlled hypertension, and heritable genetic variants. The altered genes predisposing to thoracic aortic disease either disrupt smooth muscle cell (SMC) contraction or adherence to an impaired extracellular matrix, or decrease canonical transforming growth factor beta (TGF-?) signaling. Paradoxically, TGF-? hyperactivity has been postulated to be the primary driver for the disease. More recently, it has been proposed that the response of aortic SMCs to the hemodynamic load on a structurally defective aorta is the primary driver of thoracic aortic disease, and that TGF-? overactivity in diseased aortas is a secondary, unproductive response to restore tissue function. The engineering of mouse models of inherited aortopathies has identified potential therapeutic agents to prevent thoracic aortic disease. Twit Text FOAVip Therapeutics Targeting Drivers of Thoracic Aortic Aneurysms and Acute Aortic Dissections: Insights from Predisposing Genes and Mouse Models ????Annu Rev Med http://www.kidney.de/pget.php?&tw=1&pmid=28099082 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28099082 #FOAvip English Wikipedia <ref>{{Cite pmid|28099082 }}</ref> Therapeutics Targeting Drivers of Thoracic Aortic Aneurysms and Acute Aortic Dissections: Insights from Predisposing Genes and Mouse Models #MMPMID28099082 Milewicz DM ; Prakash SK ; Ramirez F Annu Rev Med 2017[Jan]; 68 (ä): 51-67 PMID28099082 show ga Thoracic aortic diseases, including aneurysms and dissections of the thoracic aorta, are a major cause of morbidity and mortality. Risk factors for thoracic aortic disease include increased hemodynamic forces on the ascending aorta, typically due to poorly controlled hypertension, and heritable genetic variants. The altered genes predisposing to thoracic aortic disease either disrupt smooth muscle cell (SMC) contraction or adherence to an impaired extracellular matrix, or decrease canonical transforming growth factor beta (TGF-?) signaling. Paradoxically, TGF-? hyperactivity has been postulated to be the primary driver for the disease. More recently, it has been proposed that the response of aortic SMCs to the hemodynamic load on a structurally defective aorta is the primary driver of thoracic aortic disease, and that TGF-? overactivity in diseased aortas is a secondary, unproductive response to restore tissue function. The engineering of mouse models of inherited aortopathies has identified potential therapeutic agents to prevent thoracic aortic disease. |Angiotensin II/*metabolism [MESH] |Animals [MESH] |Antihypertensive Agents/therapeutic use [MESH] |Aortic Aneurysm, Thoracic/*genetics/metabolism/prevention & control [MESH] |Aortic Dissection/*genetics/metabolism/prevention & control [MESH] |Disease Models, Animal [MESH] |Genetic Predisposition to Disease [MESH] |Humans [MESH] |Losartan/therapeutic use [MESH] |Marfan Syndrome/genetics/*therapy [MESH] |Mechanoreceptors [MESH] |Mice [MESH] |Muscle, Smooth, Vascular/physiopathology [MESH] |Signal Transduction [MESH]Therapeutics Targeting Drivers of Thoracic Aortic Aneurysms and Acute (epmc).pdf DeepDyve Pubget Overpricing