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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Vet+World
2017 ; 10
(6
): 711-715
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Honey can repairing damage of liver tissue due to protein energy malnutrition
through induction of endogenous stem cells
#MMPMID28717326
Prasetyo RH
; Hestianah EP
Vet World
2017[Jun]; 10
(6
): 711-715
PMID28717326
show ga
AIM: This study was to evaluate effect of honey in repairing damage of liver
tissue due to energy protein malnutrition and in mobilization of endogenous stem
cells. MATERIALS AND METHODS: Male mice model of degenerative liver was obtained
through food fasting but still have drinking water for 5 days. It caused energy
protein malnutrition and damage of liver tissue. The administration of 50% (v/v)
honey was performed for 10 consecutive days, while the positive control group was
fasted and not given honey and the negative control not fasted and without honey.
Observations of regeneration the liver tissue based on histologically
examination, observation of Hsp70 expression, and homing signal based on vascular
endothelial growth factor-1 (VEGF-1) expression using immunohistochemistry
technique. Observation on expression of CD34 and CD45 as the marker of auto
mobilization of hematopoietic stem cells using flow cytometry technique. RESULTS:
There is regeneration of the liver tissue due to protein energy malnutrition,
decrease of Hsp70 expression, increase of VEGF-1 expression, and high expression
of CD34 and CD45. CONCLUSION: Honey can improve the liver tissue based on: (1)
Mobilization of endogenous stem cells (CD34 and CD45); (2) Hsp70 and VEGF-1
expressions as regeneration marker of improvement, and (3) regeneration
histologically of liver tissue.