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10.1186/s13048-017-0329-0 http://scihub22266oqcxt.onion/10.1186/s13048-017-0329-0 C5499000!5499000 !28679402     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28679402 &cmd=llinks): Failed to open stream: HTTP request failed! 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WAP four-disulfide core domain protein 2 promotes metastasis of human ovarian cancer by regulation of metastasis-associated genes |pdf=|usr=}}{{28679402 }} gab.com Text WAP four-disulfide core domain protein 2 promotes metastasis of human ovarian cancer by regulation of metastasis-associated genes JO: J Ovarian Res http://www.kidney.de/pget.php?&tw=1&pmid=28679402 #FOAvip BACKGROUND: WAP four-disulfide core domain protein 2 (WFDC2) shows a tumor-restricted upregulated pattern of expression in ovarian cancer. METHODS: In this study, we evaluated the role of WFCD2 in tumor mobility, invasion and metastasis of ovarian cancer in clinical tissue and in ovarian cancer cells, both in vitro and in vivo. RESULTS: Our results revealed WFCD2 was overexpressed in ovarian tissues, and the expression level of WFCD2 was associated with metastasis and lymph node metastasis. Higher expression of WFCD2 was also observed in aggressive HO8910-PM cells than in HO8910 cells, and WFCD2 knockdown halted cell migration, invasion, tumorigenicity and metastasis in ovarian cancer cells, both in vitro and in vivo. Knockdown of WFDC2 induced the down-regulation of ICAM-1, CD44, and MMP2. CONCLUSION: In summary, our work demonstrates that WFCD2 promotes metastasis in ovarian cancer. These findings suggest that WFCD2 plays a critical role in promoting metastasis and may constitute a potential therapeutic target of ovarian cancer. Twit Text FOAVip WAP four-disulfide core domain protein 2 promotes metastasis of human ovarian cancer by regulation of metastasis-associated genes ????J Ovarian Res http://www.kidney.de/pget.php?&tw=1&pmid=28679402 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28679402 #FOAvip English Wikipedia <ref>{{Cite pmid|28679402 }}</ref> WAP four-disulfide core domain protein 2 promotes metastasis of human ovarian cancer by regulation of metastasis-associated genes #MMPMID28679402 Chen Y ; Huang L ; Wang S ; Liu T ; Wu Y ; Li JL ; Li M J Ovarian Res 2017[Jul]; 10 (1 ): 40 PMID28679402 show ga BACKGROUND: WAP four-disulfide core domain protein 2 (WFDC2) shows a tumor-restricted upregulated pattern of expression in ovarian cancer. METHODS: In this study, we evaluated the role of WFCD2 in tumor mobility, invasion and metastasis of ovarian cancer in clinical tissue and in ovarian cancer cells, both in vitro and in vivo. RESULTS: Our results revealed WFCD2 was overexpressed in ovarian tissues, and the expression level of WFCD2 was associated with metastasis and lymph node metastasis. Higher expression of WFCD2 was also observed in aggressive HO8910-PM cells than in HO8910 cells, and WFCD2 knockdown halted cell migration, invasion, tumorigenicity and metastasis in ovarian cancer cells, both in vitro and in vivo. Knockdown of WFDC2 induced the down-regulation of ICAM-1, CD44, and MMP2. CONCLUSION: In summary, our work demonstrates that WFCD2 promotes metastasis in ovarian cancer. These findings suggest that WFCD2 plays a critical role in promoting metastasis and may constitute a potential therapeutic target of ovarian cancer. |*Gene Expression Regulation, Neoplastic [MESH] |Adult [MESH] |Aged [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Cell Movement/genetics [MESH] |Cell Proliferation [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Gene Knockdown Techniques [MESH] |Heterografts [MESH] |Humans [MESH] |Hyaluronan Receptors/genetics/metabolism [MESH] |Intercellular Adhesion Molecule-1/genetics/metabolism [MESH] |Matrix Metalloproteinase 2/genetics/metabolism [MESH] |Mice [MESH] |Middle Aged [MESH] |Neoplasm Grading [MESH] |Neoplasm Metastasis [MESH] |Neoplasm Staging [MESH] |Ovarian Neoplasms/*genetics/*metabolism/pathology [MESH] |Proteins/genetics/*metabolism [MESH]WAP four-disulfide core domain protein 2 promotes metastasis of human (epmc).pdf DeepDyve Pubget Overpricing