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10.1016/j.ymthe.2017.04.005 http://scihub22266oqcxt.onion/10.1016/j.ymthe.2017.04.005 C5498809!5498809!28457664     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Ther 2017 ; 25 (7): 1588-95 Nephropedia Template TP {{tp|p=28457664|t=2017. In Vivo Delivery and Therapeutic Effects of a MicroRNA on Colorectal Liver Metastases |pdf=|usr=}}{{28457664}} gab.com Text In Vivo Delivery and Therapeutic Effects of a MicroRNA on Colorectal Liver Metastases JO: Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=28457664 #FOAvip Multiple therapeutic agents are typically used in concert to effectively control metastatic tumors. Recently, we described microRNAs that are associated with the oligometastatic state, in which a limited number of metastatic tumors progress to more favorable outcomes. Here, we report the effective delivery of an oligometastatic microRNA (miR-655-3p) to colorectal liver metastases using nanoscale coordination polymers (NCPs). The NCPs demonstrated a targeted and prolonged distribution of microRNAs to metastatic liver tumors. Tumor-targeted microRNA miR-655-3p suppressed tumor growth when co-delivered with oxaliplatin, suggesting additive or synergistic interactions between microRNAs and platinum drugs. This is the first known example of systemically administered nanoparticles delivering an oligometastatic microRNA to advanced metastatic liver tumors and demonstrating tumor-suppressive effects. Our results suggest a potential therapeutic strategy for metastatic liver disease by the co-delivery of microRNAs and conventional cytotoxic agents using tumor-specific NCPs. Twit Text FOAVip In Vivo Delivery and Therapeutic Effects of a MicroRNA on Colorectal Liver Metastases ????Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=28457664 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28457664 #FOAvip English Wikipedia <ref>{{Cite pmid|28457664}}</ref> In Vivo Delivery and Therapeutic Effects of a MicroRNA on Colorectal Liver Metastases #MMPMID28457664 Oshima G; Guo N; He C; Stack ME; Poon C; Uppal A; Wightman SC; Parekh A; Skowron KB; Posner MC; Lin W; Khodarev NN; Weichselbaum RR Mol Ther 2017[Jul]; 25 (7): 1588-95 PMID28457664show ga Multiple therapeutic agents are typically used in concert to effectively control metastatic tumors. Recently, we described microRNAs that are associated with the oligometastatic state, in which a limited number of metastatic tumors progress to more favorable outcomes. Here, we report the effective delivery of an oligometastatic microRNA (miR-655-3p) to colorectal liver metastases using nanoscale coordination polymers (NCPs). The NCPs demonstrated a targeted and prolonged distribution of microRNAs to metastatic liver tumors. Tumor-targeted microRNA miR-655-3p suppressed tumor growth when co-delivered with oxaliplatin, suggesting additive or synergistic interactions between microRNAs and platinum drugs. This is the first known example of systemically administered nanoparticles delivering an oligometastatic microRNA to advanced metastatic liver tumors and demonstrating tumor-suppressive effects. Our results suggest a potential therapeutic strategy for metastatic liver disease by the co-delivery of microRNAs and conventional cytotoxic agents using tumor-specific NCPs. äIn Vivo Delivery and Therapeutic Effects of a MicroRNA on Colorectal L(epmc).pdf DeepDyve Pubget Overpricing