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10.3851/IMP3124 http://scihub22266oqcxt.onion/10.3851/IMP3124 C5498264!5498264!28054933     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28054933&cmd=llinks): Failed to open stream: HTTP request failed! 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Association of HIV infection with biomarkers of kidney injury and fibrosis in the Multicenter AIDS Cohort Study |pdf=|usr=}}{{28054933}} gab.com Text Association of HIV infection with biomarkers of kidney injury and fibrosis in the Multicenter AIDS Cohort Study JO: Antivir Ther http://www.kidney.de/pget.php?&tw=1&pmid=28054933 #FOAvip Background: Chronic kidney disease (CKD) is common among HIV-infected individuals, but serum creatinine is insensitive for detecting kidney damage at early stages. We hypothesized that HIV infection would be associated with elevations in subclinical markers of kidney injury and fibrosis in a contemporary cohort of men. Methods: In this cross-sectional study, we measured urine levels of interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1), pro-collagen type III N-terminal pro-peptide (PIIINP), and albumin-creatinine ratio (ACR) in 813 HIV-infected and 331 uninfected men enrolled in the Multicenter AIDS Cohort Study. Results: Median eGFR was 95 ml/min/1.73m2 among African-Americans (n=376) and 87 ml/min/1.73m2 among Caucasians (n=768). Among HIV-infected men, the median CD4 lymphocyte count was 572 cells/mm3 and 76% of men had undetectable HIV RNA levels. After multivariable adjustment for traditional CKD risk factors including eGFR, HIV infection was associated with 52% higher urine IL-18 (95% CI: 33%, 73%), 44% higher KIM-1 (27%, 64%), 30% higher PIIINP (15%, 47%), and 84% higher ACR (54%, 120%), with similar effect sizes among African-Americans and Caucasians (p>0.2 for tests of interaction by race). These associations remained statistically significant in analyses that excluded persons with detectable HIV RNA levels and in models that adjusted for cumulative exposure to tenofovir disoproxil fumarate. Conclusions: Compared with uninfected men, HIV-infected men had more extensive glomerular and tubulointerstitial damage, as assessed by urine biomarkers. Future studies should evaluate whether combinations of biomarkers can be used to monitor stages of kidney injury and to predict CKD risk in HIV-infected individuals. Twit Text FOAVip Association of HIV infection with biomarkers of kidney injury and fibrosis in the Multicenter AIDS Cohort Study ????Antivir Ther http://www.kidney.de/pget.php?&tw=1&pmid=28054933 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28054933 #FOAvip English Wikipedia <ref>{{Cite pmid|28054933}}</ref> Association of HIV infection with biomarkers of kidney injury and fibrosis in the Multicenter AIDS Cohort Study #MMPMID28054933 Jotwani V; Scherzer R; Estrella MM; Jacobson LP; Witt MD; Palella F; Ho K; Bennett M; Parikh CR; Ix JH; Shlipak M Antivir Ther 2017[]; 22 (5): 421-9 PMID28054933show ga Background: Chronic kidney disease (CKD) is common among HIV-infected individuals, but serum creatinine is insensitive for detecting kidney damage at early stages. We hypothesized that HIV infection would be associated with elevations in subclinical markers of kidney injury and fibrosis in a contemporary cohort of men. Methods: In this cross-sectional study, we measured urine levels of interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1), pro-collagen type III N-terminal pro-peptide (PIIINP), and albumin-creatinine ratio (ACR) in 813 HIV-infected and 331 uninfected men enrolled in the Multicenter AIDS Cohort Study. Results: Median eGFR was 95 ml/min/1.73m2 among African-Americans (n=376) and 87 ml/min/1.73m2 among Caucasians (n=768). Among HIV-infected men, the median CD4 lymphocyte count was 572 cells/mm3 and 76% of men had undetectable HIV RNA levels. After multivariable adjustment for traditional CKD risk factors including eGFR, HIV infection was associated with 52% higher urine IL-18 (95% CI: 33%, 73%), 44% higher KIM-1 (27%, 64%), 30% higher PIIINP (15%, 47%), and 84% higher ACR (54%, 120%), with similar effect sizes among African-Americans and Caucasians (p>0.2 for tests of interaction by race). These associations remained statistically significant in analyses that excluded persons with detectable HIV RNA levels and in models that adjusted for cumulative exposure to tenofovir disoproxil fumarate. Conclusions: Compared with uninfected men, HIV-infected men had more extensive glomerular and tubulointerstitial damage, as assessed by urine biomarkers. Future studies should evaluate whether combinations of biomarkers can be used to monitor stages of kidney injury and to predict CKD risk in HIV-infected individuals. äAssociation of HIV infection with biomarkers of kidney injury and fibr(epmc).pdf DeepDyve Pubget Overpricing