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10.1038/nm.4278 http://scihub22266oqcxt.onion/10.1038/nm.4278 C5497996!5497996!28165478     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2017 ; 23 (3): 368-75 Nephropedia Template TP {{tp|p=28165478|t=2017. A distinct innate lymphoid cell population regulates tumor-associated T cells |pdf=|usr=}}{{28165478}} gab.com Text A distinct innate lymphoid cell population regulates tumor-associated T cells JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=28165478 #FOAvip Antitumor T cells are subject to multiple mechanisms of negative regulation1?3. Recent findings that innate lymphoid cells (ILCs) regulate adaptive T cell responses4?6 led us to examine the regulatory potential of ILCs in the context of cancer. We identified a unique ILC population that inhibits tumor-infiltrating lymphocytes (TILs) from high-grade serous tumors, defined their suppressive capacity in vitro, and performed a comprehensive analysis of their phenotype. Notably, the presence of this CD56+CD3? population in TIL cultures was associated with reduced T cell numbers, and further functional studies demonstrated that this population suppressed TIL expansion and altered TIL cytokine production. Transcriptome analysis and phenotypic characterization determined that regulatory CD56+CD3? cells exhibit low cytotoxic activity, produce IL-22, and have an expression profile that overlaps with those of natural killer (NK) cells and other ILCs. NKp46 was highly expressed by these cells, and addition of anti-NKp46 antibodies to TIL cultures abrogated the ability of these regulatory ILCs to suppress T cell expansion. Notably, the presence of these regulatory ILCs in TIL cultures corresponded with a striking reduction in the time to disease recurrence. These studies demonstrate that a previously uncharacterized ILC population regulates the activity and expansion of tumor-associated T cells. Twit Text FOAVip A distinct innate lymphoid cell population regulates tumor-associated T cells ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=28165478 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28165478 #FOAvip English Wikipedia <ref>{{Cite pmid|28165478}}</ref> A distinct innate lymphoid cell population regulates tumor-associated T cells #MMPMID28165478 Crome SQ; Nguyen LT; Lopez-Verges S; Yang SYC; Martin B; Yam JY; Johnson DJ; Nie J; Pniak M; Yen PH; Milea A; Sowamber R; Katz SR; Bernardini MQ; Clarke BA; Shaw PA; Lang PA; Berman HK; Pugh TJ; Lanier LL; Ohashi PS Nat Med 2017[Mar]; 23 (3): 368-75 PMID28165478show ga Antitumor T cells are subject to multiple mechanisms of negative regulation1?3. Recent findings that innate lymphoid cells (ILCs) regulate adaptive T cell responses4?6 led us to examine the regulatory potential of ILCs in the context of cancer. We identified a unique ILC population that inhibits tumor-infiltrating lymphocytes (TILs) from high-grade serous tumors, defined their suppressive capacity in vitro, and performed a comprehensive analysis of their phenotype. Notably, the presence of this CD56+CD3? population in TIL cultures was associated with reduced T cell numbers, and further functional studies demonstrated that this population suppressed TIL expansion and altered TIL cytokine production. Transcriptome analysis and phenotypic characterization determined that regulatory CD56+CD3? cells exhibit low cytotoxic activity, produce IL-22, and have an expression profile that overlaps with those of natural killer (NK) cells and other ILCs. NKp46 was highly expressed by these cells, and addition of anti-NKp46 antibodies to TIL cultures abrogated the ability of these regulatory ILCs to suppress T cell expansion. Notably, the presence of these regulatory ILCs in TIL cultures corresponded with a striking reduction in the time to disease recurrence. These studies demonstrate that a previously uncharacterized ILC population regulates the activity and expansion of tumor-associated T cells. äA distinct innate lymphoid cell population regulates tumor-associated (epmc).pdf DeepDyve Pubget Overpricing