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2017 ; 12
(7
): e0180256
Nephropedia Template TP
gab.com Text
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Preliminary fast diagnosis of severe fever with thrombocytopenia syndrome with
clinical and epidemiological parameters
#MMPMID28678811
Hu J
; Li Z
; Hong L
; Bao C
; Zhang Z
; Zhang H
; He H
; Wang X
; Liu W
; Peng Z
; Shi L
; Zhu F
PLoS One
2017[]; 12
(7
): e0180256
PMID28678811
show ga
OBJECTIVES: To identify specific clinical and epidemiological parameters for
clinical diagnosis of SFTSV infection with relatively higher accuracy. METHODS:
231 suspected cases of SFTS were reported by various medical institutions from
2011 to 2013 in Jiangsu Province, China. They were followed with SFTSV diagnosis
tests and interview-administered questionnaires about demographic
characteristics, clinical symptoms and epidemiological exposure factors.
Univariate and multivariable logistic regression analysis were used to examine
the diagnostic value of these parameters. RESULTS: SFTSV infection occurred only
from April to October annually and usually in hilly areas of specific regions.
Three prediction models of SFTSV infection were constructed. Model 3 with
clinical and epidemiological parameters combined the benefits of both Model 1and
Model 2, which was optimal and had an overall accuracy of 80.2%. Independent
indicators for clinical diagnosis of SFTSV infection in Model 3 were as follows:
lymphadenopathy (P = 0.01), leucopenia (P<0.01), age >50 years (P = 0.01), tick
bites (P<0.01), raising domestic animals in the residential areas (P<0.01) and
farming (P = 0.03). CONCLUSIONS: Our results show that using a combination of
clinical and epidemiological parameters may be a feasible strategy to provide
preliminary fast diagnosis as differentiating SFTSV infection from SFTS-like
diseases, thus reducing the risk of misdiagnosis.