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10.1111/cas.13276 http://scihub22266oqcxt.onion/10.1111/cas.13276 C5497928!5497928 !28498503     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28498503 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28498503 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Sci 2017 ; 108 (7 ): 1405-1413 Nephropedia Template TP {{tp|p=28498503 |t=2017. p62/SQSTM1 as an oncotarget mediates cisplatin resistance through activating RIP1-NF-?B pathway in human ovarian cancer cells |pdf=|usr=}}{{28498503 }} gab.com Text p62/SQSTM1 as an oncotarget mediates cisplatin resistance through activating RIP1-NF- B pathway in human ovarian cancer cells JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28498503 #FOAvip Platinum-based therapeutic strategies have been widely used in ovarian cancer treatment. However, drug resistance has greatly limited therapeutic efficacy. Recently, tolerance to cisplatin has been attributed to other factors unrelated to DNA. p62 (also known as SQSTM1) functions as a multifunctional hub participating in tumorigenesis and may be a therapeutic target. Our previous study showed that p62 was overexpressed in drug-resistant ovarian epithelial carcinoma and its inhibition increased the sensitivity to cisplatin. In this study, we demonstrate that the activity of the NF-?B signaling pathway and K63-linked ubiquitination of RIP1 was higher in cisplatin-resistant ovarian (SKOV3/DDP) cells compared with parental cells. In addition, cisplatin resistance could be reversed by inhibiting the expression of p62 using siRNA. Furthermore, deletion of the ZZ domain of p62 that interacts with RIP1 in SKOV3 cells markedly decreased K63-linked ubiquitination of RIP1 and inhibited the activation of the NF-?B signaling pathway. Moreover, loss of the ZZ domain from p62 led to poor proliferative capacity and high levels of apoptosis in SKOV3 cells and made them more sensitive to cisplatin treatment. Collectively, we provide evidence that p62 is implicated in the activation of NF-?B signaling that is partly dependent on RIP1. p62 promotes cell proliferation and inhibits apoptosis thus mediating drug resistance in ovarian cancer cells. Twit Text FOAVip p62/SQSTM1 as an oncotarget mediates cisplatin resistance through activating RIP1-NF- B pathway in human ovarian cancer cells ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28498503 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28498503 #FOAvip English Wikipedia <ref>{{Cite pmid|28498503 }}</ref> p62/SQSTM1 as an oncotarget mediates cisplatin resistance through activating RIP1-NF-?B pathway in human ovarian cancer cells #MMPMID28498503 Yan XY ; Zhang Y ; Zhang JJ ; Zhang LC ; Liu YN ; Wu Y ; Xue YN ; Lu SY ; Su J ; Sun LK Cancer Sci 2017[Jul]; 108 (7 ): 1405-1413 PMID28498503 show ga Platinum-based therapeutic strategies have been widely used in ovarian cancer treatment. However, drug resistance has greatly limited therapeutic efficacy. Recently, tolerance to cisplatin has been attributed to other factors unrelated to DNA. p62 (also known as SQSTM1) functions as a multifunctional hub participating in tumorigenesis and may be a therapeutic target. Our previous study showed that p62 was overexpressed in drug-resistant ovarian epithelial carcinoma and its inhibition increased the sensitivity to cisplatin. In this study, we demonstrate that the activity of the NF-?B signaling pathway and K63-linked ubiquitination of RIP1 was higher in cisplatin-resistant ovarian (SKOV3/DDP) cells compared with parental cells. In addition, cisplatin resistance could be reversed by inhibiting the expression of p62 using siRNA. Furthermore, deletion of the ZZ domain of p62 that interacts with RIP1 in SKOV3 cells markedly decreased K63-linked ubiquitination of RIP1 and inhibited the activation of the NF-?B signaling pathway. Moreover, loss of the ZZ domain from p62 led to poor proliferative capacity and high levels of apoptosis in SKOV3 cells and made them more sensitive to cisplatin treatment. Collectively, we provide evidence that p62 is implicated in the activation of NF-?B signaling that is partly dependent on RIP1. p62 promotes cell proliferation and inhibits apoptosis thus mediating drug resistance in ovarian cancer cells. |Antineoplastic Agents/pharmacology [MESH] |Blotting, Western [MESH] |Carcinoma, Ovarian Epithelial [MESH] |Cell Line, Tumor [MESH] |Cisplatin/pharmacology [MESH] |Drug Resistance, Neoplasm/*physiology [MESH] |Female [MESH] |Flow Cytometry [MESH] |Fluorescent Antibody Technique [MESH] |Humans [MESH] |Immunoprecipitation [MESH] |Microscopy, Confocal [MESH] |NF-kappa B/*metabolism [MESH] |Neoplasms, Glandular and Epithelial/metabolism/*pathology [MESH] |Nuclear Pore Complex Proteins/*metabolism [MESH] |Ovarian Neoplasms/metabolism/*pathology [MESH] |RNA-Binding Proteins/*metabolism [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Sequestosome-1 Protein/*metabolism [MESH]p62/SQSTM1 as an oncotarget mediates cisplatin resistance through acti(epmc).pdf DeepDyve Pubget Overpricing