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2016 ; 7
(5
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Maintenance and Intensification of Bivalent Oral Poliovirus Vaccine Use Prior to
its Coordinated Global Cessation
#MMPMID28690915
Tebbens RJD
; Hampton LM
; Wassilak SGF
; Pallansch MA
; Cochi SL
; Thompson KM
J Vaccines Vaccin
2016[Oct]; 7
(5
): ä PMID28690915
show ga
OBJECTIVE: To examine the impact of different bivalent oral poliovirus vaccine
(bOPV) supplemental immunization activity (SIA) strategies on population immunity
to serotype 1 and 3 poliovirus transmission and circulating vaccine-derived
poliovirus (cVDPV) risks before and after globally-coordinated cessation of
serotype 1 and 3 oral poliovirus vaccine (OPV13 cessation). METHODS: We adapt
mathematical models that previously informed vaccine choices ahead of the
trivalent oral poliovirus vaccine to bOPV switch to estimate the population
immunity to serotype 1 and 3 poliovirus transmission needed at the time of OPV13
cessation to prevent subsequent cVDPV outbreaks. We then examine the impact of
different frequencies of SIAs using bOPV in high risk populations on population
immunity to serotype 1 and 3 transmission, on the risk of serotype 1 and 3 cVDPV
outbreaks, and on the vulnerability to any imported bOPV-related polioviruses.
RESULTS: Maintaining high population immunity to serotype 1 and 3 transmission
using bOPV SIAs significantly reduces 1) the risk of outbreaks due to imported
serotype 1 and 3 viruses, 2) the emergence of indigenous cVDPVs before or after
OPV13 cessation, and 3) the vulnerability to bOPV-related polioviruses in the
event of non-synchronous OPV13 cessation or inadvertent bOPV use after OPV13
cessation. CONCLUSION: Although some reduction in global SIA frequency can safely
occur, countries with suboptimal routine immunization coverage should each
continue to conduct at least one annual SIA with bOPV, preferably more, until
global OPV13 cessation. Preventing cVDPV risks after OPV13 cessation requires
investments in bOPV SIAs now through the time of OPV13 cessation.