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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cardiovasc+Intervent+Radiol 2015 ; 38 (1): 182-90 Nephropedia Template TP
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Planning Irreversible Electroporation (IRE) in the Porcine Kidney: Are Numerical Simulations Reliable for Predicting Empiric Ablation Outcomes? #MMPMID24831827
Cardiovasc Intervent Radiol 2015[Feb]; 38 (1): 182-90 PMID24831827show ga
Purpose: Numerical simulations are used for treatment planning in clinical applications of irreversible electroporation (IRE) to determine ablation size and shape. To assess the reliability of simulations for treatment planning, we compared simulation results with empiric outcomes of renal IRE using computed tomography (CT) and histology in an animal model. Materials and Methods: The ablation size and shape for 6 different IRE parameter sets (70?90 pulses, 2000?2700V, 70?100?s) for monopolar and bipolar electrodes was simulated using a numerical model. Employing these treatment parameters 35 CT-guided IRE ablations were created in both kidneys of 6 pigs and followed-up with CT immediately and after 24 hours. Histopathology was analyzed from post-ablation day 1. Results: Ablation zones on CT measured 81±18% (day 0, p?0.05) and 115±18% (day 1, p?0.09) of the simulated size for monopolar electrodes, 190±33% (day 0, p?0.001) and 234±12% (day 1, p?0.0001) for bipolar electrodes. Histopathology indicated smaller ablation zones than simulated (71±41%, p?0.047) and measured on CT (47±16%, p?0.005) with complete ablation of kidney parenchyma within the central zone and incomplete ablation in the periphery. Conclusions: Both numerical simulations for planning renal IRE and CT measurements may overestimate the size of ablation when compared to histology and ablation effects may be incomplete in the periphery.