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2017 ; 8
(2
): 50-53
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Efficacy of Atorvastatin in Prevention of Contrast-induced Nephropathy in
High-risk Patients Undergoing Angiography: A Double-blind Randomized Controlled
Trial
#MMPMID28706398
Syed MH
; Khandelwal PN
; Thawani VR
; Katare SS
J Pharmacol Pharmacother
2017[Apr]; 8
(2
): 50-53
PMID28706398
show ga
OBJECTIVE: To evaluate the efficacy and safety of atorvastatin (ATN) 80 mg in the
prevention of contrast medium- induced nephropathy (CIN) in high risk patients
undergoing angiograph. MATERIALS AND METHODS: This was a prospective,
double-blind, two-arm, parallel group RCT. A total of 216 patients undergoing
coronary angiography were screened, and 188 eligible patients were randomized to
two treatment arms. Patients in Group A received tablet N-acetylcysteine (NAC)
1200 mg once daily, and patients in Group B received tablet atorvastatin 80 mg +
NAC 1200 mg once daily, for 3 days before, and 2 days after angiography. RESULTS:
A total of 160 patients completed the trial. Postprocedure, nine and two CIN
cases were found in Group A and B, respectively. The mean change in serum
creatinine was 0.086 ± 0.168 in Group A and 0.021 ± 0.083 in Group B, which was
statistically significant (P = 0.0289). Postprocedure, the estimated glomerular
filteration rate was reduced by 19.52 in Group A and 13.55 in Group B (P =
0.003). CONCLUSION: This trial indicates the positive role of statins in
preventive strategy against CIN along with NAC.