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10.4103/jpp.JPP_156_16

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suck abstract from ncbi


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pmid28706398
      J+Pharmacol+Pharmacother 2017 ; 8 (2 ): 50-53
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  • Efficacy of Atorvastatin in Prevention of Contrast-induced Nephropathy in High-risk Patients Undergoing Angiography: A Double-blind Randomized Controlled Trial #MMPMID28706398
  • Syed MH ; Khandelwal PN ; Thawani VR ; Katare SS
  • J Pharmacol Pharmacother 2017[Apr]; 8 (2 ): 50-53 PMID28706398 show ga
  • OBJECTIVE: To evaluate the efficacy and safety of atorvastatin (ATN) 80 mg in the prevention of contrast medium- induced nephropathy (CIN) in high risk patients undergoing angiograph. MATERIALS AND METHODS: This was a prospective, double-blind, two-arm, parallel group RCT. A total of 216 patients undergoing coronary angiography were screened, and 188 eligible patients were randomized to two treatment arms. Patients in Group A received tablet N-acetylcysteine (NAC) 1200 mg once daily, and patients in Group B received tablet atorvastatin 80 mg + NAC 1200 mg once daily, for 3 days before, and 2 days after angiography. RESULTS: A total of 160 patients completed the trial. Postprocedure, nine and two CIN cases were found in Group A and B, respectively. The mean change in serum creatinine was 0.086 ± 0.168 in Group A and 0.021 ± 0.083 in Group B, which was statistically significant (P = 0.0289). Postprocedure, the estimated glomerular filteration rate was reduced by 19.52 in Group A and 13.55 in Group B (P = 0.003). CONCLUSION: This trial indicates the positive role of statins in preventive strategy against CIN along with NAC.
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