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2017 ; 7
(1
): 4586
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Identifying the neck margin status of ductal adenocarcinoma in the pancreatic
head by multiphoton microscopy
#MMPMID28676646
Xu J
; Chen Y
; Chen H
; Hong Z
; Shi Z
; Zhuo S
; Zhu X
; Chen J
Sci Rep
2017[Jul]; 7
(1
): 4586
PMID28676646
show ga
Complete surgical resection is the only option for improving the survival of
patients with ductal adenocarcinoma in the pancreatic head. After resection,
determining the status of resection margins (RMs) is crucial for deciding on the
nature of the follow-up treatment. The purpose of this study was to evaluate
whether multiphoton microscopy (MPM) could be considered a reliable tool for
determining the status of pancreatic neck margins by identifying tumour cells of
ductal adenocarcinoma in these margins in the pancreatic head, and our results
were affirmative. In particular, MPM could identify tumour cells in the nerves.
It was also found that the quantification of the difference between normal duct
cells and tumour cells was possible. In addition, the content of collagen could
be quantified and used as a marker for differentiating ductal adenocarcinoma in
the pancreatic head from normal pancreatic tissues, eventually leading to the
identification of R0 and R1 resections of the pancreatic neck margin. With the
development of the clinical applications of the multiphoton endoscope, MPM has
the potential to provide in vivo real-time identification of RM status during
surgery.