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10.1038/s41598-017-04894-0 http://scihub22266oqcxt.onion/10.1038/s41598-017-04894-0 C5496856!5496856 !28676677     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28676677 &cmd=llinks): Failed to open stream: HTTP request failed! 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HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8(+) T cells |pdf=|usr=}}{{28676677 }} gab.com Text HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8(+) T cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28676677 #FOAvip Infection with Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis, remains a global health concern. Both classically and non-classically restricted cytotoxic CD8(+) T cells are important to the control of Mtb infection. We and others have demonstrated that the non-classical MHC I molecule HLA-E can present pathogen-derived peptides to CD8(+) T cells. In this manuscript, we identified the antigen recognized by an HLA-E-restricted CD8(+) T cell clone isolated from an Mtb latently infected individual as a peptide from the Mtb protein, MPT32. Recognition by the CD8(+) T cell clone required N-terminal O-linked mannosylation of MPT32 by a mannosyltransferase encoded by the Rv1002c gene. This is the first description of a post-translationally modified Mtb-derived protein antigen presented in the context of an HLA-E specific CD8(+) T cell immune response. The identification of an immune response that targets a unique mycobacterial modification is novel and may have practical impact in the development of vaccines and diagnostics. Twit Text FOAVip HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8(+) T cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28676677 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28676677 #FOAvip English Wikipedia <ref>{{Cite pmid|28676677 }}</ref> HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8(+) T cells #MMPMID28676677 Harriff MJ ; Wolfe LM ; Swarbrick G ; Null M ; Cansler ME ; Canfield ET ; Vogt T ; Toren KG ; Li W ; Jackson M ; Lewinsohn DA ; Dobos KM ; Lewinsohn DM Sci Rep 2017[Jul]; 7 (1 ): 4622 PMID28676677 show ga Infection with Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis, remains a global health concern. Both classically and non-classically restricted cytotoxic CD8(+) T cells are important to the control of Mtb infection. We and others have demonstrated that the non-classical MHC I molecule HLA-E can present pathogen-derived peptides to CD8(+) T cells. In this manuscript, we identified the antigen recognized by an HLA-E-restricted CD8(+) T cell clone isolated from an Mtb latently infected individual as a peptide from the Mtb protein, MPT32. Recognition by the CD8(+) T cell clone required N-terminal O-linked mannosylation of MPT32 by a mannosyltransferase encoded by the Rv1002c gene. This is the first description of a post-translationally modified Mtb-derived protein antigen presented in the context of an HLA-E specific CD8(+) T cell immune response. The identification of an immune response that targets a unique mycobacterial modification is novel and may have practical impact in the development of vaccines and diagnostics. |A549 Cells [MESH] |Antigen Presentation [MESH] |Antigens, Bacterial/*immunology [MESH] |CD8-Positive T-Lymphocytes/*immunology [MESH] |Epitopes, T-Lymphocyte/immunology [MESH] |Glycopeptides/immunology [MESH] |HEK293 Cells [MESH] |HLA-E Antigens [MESH] |Histocompatibility Antigens Class I/*immunology [MESH] |Humans [MESH] |Mannose/metabolism [MESH] |Mycobacterium tuberculosis/immunology/*metabolism [MESH] |Protein Processing, Post-Translational [MESH]HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Prote(epmc).pdf DeepDyve Pubget Overpricing