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2017 ; 11
(7
): 770-780
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Cancer metastasis through the prism of epithelial-to-mesenchymal transition in
circulating tumor cells
#MMPMID28544498
Micalizzi DS
; Haber DA
; Maheswaran S
Mol Oncol
2017[Jul]; 11
(7
): 770-780
PMID28544498
show ga
Metastasis of epithelial cancer cells to distant sites is a particularly critical
stage of cancer progression that typically marks the incurability of the disease.
It is governed by a complex series of events including invasion and intravasation
of tumor cells into the stroma and blood, respectively. Epithelial-to-mesenchymal
transition (EMT), a phenotypic change marked by the loss of epithelial
characteristics and the acquisition of invasive mesenchymal properties, is
implicated in the dissemination of tumor cells. Circulating tumor cells (CTCs),
the precursors of metastasis, can be used to interrogate the contribution of EMT
in metastasis and therapeutic responses. The analysis of these CTCs and in
particular the presence of inter- and intrapatient heterogeneity for markers of
EMT has provided new insights into the metastatic process. This review will focus
on epithelial-mesenchymal plasticity in CTCs and its potential clinical
implications.