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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Ann+Rheum+Dis
2017 ; 76
(5
): 792-801
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
2016 American College of Rheumatology/European League Against Rheumatism criteria
for minimal, moderate, and major clinical response in adult dermatomyositis and
polymyositis: An International Myositis Assessment and Clinical Studies
Group/Paediatric Rheumatology International Trials Organisation Collaborative
Initiative
#MMPMID28385805
Aggarwal R
; Rider LG
; Ruperto N
; Bayat N
; Erman B
; Feldman BM
; Oddis CV
; Amato AA
; Chinoy H
; Cooper RG
; Dastmalchi M
; Fiorentino D
; Isenberg D
; Katz JD
; Mammen A
; de Visser M
; Ytterberg SR
; Lundberg IE
; Chung L
; Danko K
; García-De la Torre I
; Song YW
; Villa L
; Rinaldi M
; Rockette H
; Lachenbruch PA
; Miller FW
; Vencovsky J
Ann Rheum Dis
2017[May]; 76
(5
): 792-801
PMID28385805
show ga
To develop response criteria for adult dermatomyositis (DM) and polymyositis
(PM). Expert surveys, logistic regression, and conjoint analysis were used to
develop 287 definitions using core set measures. Myositis experts rated greater
improvement among multiple pairwise scenarios in conjoint analysis surveys, where
different levels of improvement in 2 core set measures were presented. The
PAPRIKA (Potentially All Pairwise Rankings of All Possible Alternatives) method
determined the relative weights of core set measures and conjoint analysis
definitions. The performance characteristics of the definitions were evaluated on
patient profiles using expert consensus (gold standard) and were validated using
data from a clinical trial. The nominal group technique was used to reach
consensus. Consensus was reached for a conjoint analysis-based continuous model
using absolute per cent change in core set measures (physician, patient, and
extramuscular global activity, muscle strength, Health Assessment Questionnaire,
and muscle enzyme levels). A total improvement score (range 0-100), determined by
summing scores for each core set measure, was based on improvement in and
relative weight of each core set measure. Thresholds for minimal, moderate, and
major improvement were ?20, ?40, and ?60 points in the total improvement score.
The same criteria were chosen for juvenile DM, with different improvement
thresholds. Sensitivity and specificity in DM/PM patient cohorts were 85% and
92%, 90% and 96%, and 92% and 98% for minimal, moderate, and major improvement,
respectively. Definitions were validated in the clinical trial analysis for
differentiating the physician rating of improvement (p<0.001). The response
criteria for adult DM/PM consisted of the conjoint analysis model based on
absolute per cent change in 6 core set measures, with thresholds for minimal,
moderate, and major improvement.
|*Severity of Illness Index
[MESH]
|Adolescent
[MESH]
|Adult
[MESH]
|Child
[MESH]
|Child, Preschool
[MESH]
|Consensus
[MESH]
|Dermatomyositis/*therapy
[MESH]
|Humans
[MESH]
|Outcome Assessment, Health Care/*standards
[MESH]