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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Lab+Physicians
2017 ; 9
(3
): 163-169
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Acylation-stimulating protein is a surrogate biomarker for acute myocardial
infarction: Role of statins
#MMPMID28706385
Al-Kuraishy HM
; Al-Gareeb AI
J Lab Physicians
2017[Jul]; 9
(3
): 163-169
PMID28706385
show ga
BACKGROUND: Acylation-stimulating protein (ASP) is an adipokine synthesized
within adipocytes environment due to adipocyte differentiation. AIM: The aim of
this study was to assess changes in ASP levels in patients with acute myocardial
infarction (MI) and to correlate these variations with disease variables.
SUBJECTS AND METHODS: A total number of 111 patients previously and currently
treated with rosuvastatin or atorvastatin presented with acute MI in a Coronary
Care Unit, were divided into three groups, Group A: Thirty-nine patients treated
with atorvastatin, Group B: Thirty patients treated with rosuvastatin, compared
to 42 patients presented with MI not previously treated with statins were
enrolled in this study. ASP and troponin-I levels and lipid profile were
estimated in each group. RESULTS: The effects of atorvastatin and rosuvastatin
compared to nonstatins-treated group on the anthropometric and biochemical
variables in patients with acute MI showed significant difference in all
biochemical and anthropometric parameters P < 0.05. Serum ASP (nmol/l) levels
were higher in control patients 57.25 ± 9.15 compared to atorvastatin-treated
patients 48.43 ± 7.42 and rosuvastatin-treated patients 49.33 ± 6.52 P = 0.0124.
CONCLUSION: ASP levels are elevated in patients with acute MI and regarded as
surrogate biomarker for acute MI also; therapy with statins leads to significant
reduction in ASP levels compared to nonstatins-treated patients that presented
with acute MI.