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10.1194/jlr.M075713 http://scihub22266oqcxt.onion/10.1194/jlr.M075713 C5496037!5496037 !28533304     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28533304 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Lipid+Res 2017 ; 58 (7 ): 1399-1416 Nephropedia Template TP {{tp|p=28533304 |t=2017. Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids |pdf=|usr=}}{{28533304 }} gab.com Text Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids JO: J Lipid Res http://www.kidney.de/pget.php?&tw=1&pmid=28533304 #FOAvip Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, yet the pathogenesis of NAFLD is only partially understood. Here, we investigated the role of the gut bacteria in NAFLD by stimulating the gut bacteria via feeding mice the fermentable dietary fiber, guar gum (GG), and suppressing the gut bacteria via chronic oral administration of antibiotics. GG feeding profoundly altered the gut microbiota composition, in parallel with reduced diet-induced obesity and improved glucose tolerance. Strikingly, despite reducing adipose tissue mass and inflammation, GG enhanced hepatic inflammation and fibrosis, concurrent with markedly elevated plasma and hepatic bile acid levels. Consistent with a role of elevated bile acids in the liver phenotype, treatment of mice with taurocholic acid stimulated hepatic inflammation and fibrosis. In contrast to GG, chronic oral administration of antibiotics effectively suppressed the gut bacteria, decreased portal secondary bile acid levels, and attenuated hepatic inflammation and fibrosis. Neither GG nor antibiotics influenced plasma lipopolysaccharide levels. In conclusion, our data indicate a causal link between changes in gut microbiota and hepatic inflammation and fibrosis in a mouse model of NAFLD, possibly via alterations in bile acids. Twit Text FOAVip Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids ????J Lipid Res http://www.kidney.de/pget.php?&tw=1&pmid=28533304 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28533304 #FOAvip English Wikipedia <ref>{{Cite pmid|28533304 }}</ref> Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids #MMPMID28533304 Janssen AWF ; Houben T ; Katiraei S ; Dijk W ; Boutens L ; van der Bolt N ; Wang Z ; Brown JM ; Hazen SL ; Mandard S ; Shiri-Sverdlov R ; Kuipers F ; Willems van Dijk K ; Vervoort J ; Stienstra R ; Hooiveld GJEJ ; Kersten S J Lipid Res 2017[Jul]; 58 (7 ): 1399-1416 PMID28533304 show ga Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, yet the pathogenesis of NAFLD is only partially understood. Here, we investigated the role of the gut bacteria in NAFLD by stimulating the gut bacteria via feeding mice the fermentable dietary fiber, guar gum (GG), and suppressing the gut bacteria via chronic oral administration of antibiotics. GG feeding profoundly altered the gut microbiota composition, in parallel with reduced diet-induced obesity and improved glucose tolerance. Strikingly, despite reducing adipose tissue mass and inflammation, GG enhanced hepatic inflammation and fibrosis, concurrent with markedly elevated plasma and hepatic bile acid levels. Consistent with a role of elevated bile acids in the liver phenotype, treatment of mice with taurocholic acid stimulated hepatic inflammation and fibrosis. In contrast to GG, chronic oral administration of antibiotics effectively suppressed the gut bacteria, decreased portal secondary bile acid levels, and attenuated hepatic inflammation and fibrosis. Neither GG nor antibiotics influenced plasma lipopolysaccharide levels. In conclusion, our data indicate a causal link between changes in gut microbiota and hepatic inflammation and fibrosis in a mouse model of NAFLD, possibly via alterations in bile acids. |*Gastrointestinal Microbiome/drug effects [MESH] |Animals [MESH] |Anti-Bacterial Agents/pharmacology [MESH] |Bile Acids and Salts/*metabolism [MESH] |Biological Transport [MESH] |Diet, High-Fat/adverse effects [MESH] |Fibrosis [MESH] |Galactans/adverse effects [MESH] |Glucose Tolerance Test [MESH] |Liver/metabolism/pathology [MESH] |Male [MESH] |Mannans/adverse effects [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Non-alcoholic Fatty Liver Disease/chemically induced/*metabolism/*microbiology/pathology [MESH] |Obesity/chemically induced/metabolism/microbiology [MESH]Modulation of the gut microbiota impacts nonalcoholic fatty liver dise(epmc).pdf DeepDyve Pubget Overpricing