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10.1194/jlr.M074229 http://scihub22266oqcxt.onion/10.1194/jlr.M074229 C5496032!5496032 !28554983     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28554983 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Lipid+Res 2017 ; 58 (7 ): 1338-1353 Nephropedia Template TP {{tp|p=28554983 |t=2017. CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induced cardiac fibrotic response by targeting G?(12/13) |pdf=|usr=}}{{28554983 }} gab.com Text CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induced cardiac fibrotic response by targeting G (12/13) JO: J Lipid Res http://www.kidney.de/pget.php?&tw=1&pmid=28554983 #FOAvip The arachidonic acid-cytochrome P450 2J2-epoxyeicosatrienoic acid (AA-CYP2J2-EET) metabolic pathway has been identified to be protective in the cardiovascular system. This study explored the effects of the AA-CYP2J2-EET metabolic pathway on cardiac fibrosis from the perspective of cardiac fibroblasts and underlying mechanisms. In in vivo studies, 8-week-old male CYP2J2 transgenic mice (aMHC-CYP2J2-Tr) and littermates were infused with angiotensin II (Ang II) or saline for 2 weeks. Results showed that CYP2J2 overexpression increased EET production. Meanwhile, impairment of cardiac function and fibrotic response were attenuated by CYP2J2 overexpression. The effects of CYP2J2 were associated with reduced activation of the ? subunits of G12 family G proteins (G?(12/13))/RhoA/Rho kinase (ROCK) cascade and elevation of the NO/cyclic guanosine monophosphate (cGMP) level in cardiac tissue. In in vitro studies, cardiac fibroblast activation, proliferation, migration, and collagen production induced by Ang II were associated with activation of the G?(12/13)/RhoA/ROCK pathway, which was inhibited by exogenous 11,12-EET. Moreover, silencing of G?(12/13) or RhoA exerted similar effects as 11,12-EET. Furthermore, inhibitory effects of 11,12-EET on G?(12/13) were blocked by NO/cGMP pathway inhibitors. Our findings indicate that enhancement of the AA-CYP2J2-EET metabolic pathway by CYP2J2 overexpression attenuates Ang II-induced cardiac dysfunction and fibrosis by reducing the fibrotic response of cardiac fibroblasts by targeting the G?(12/13)/RhoA/ROCK pathway via NO/cGMP signaling. Twit Text FOAVip CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induced cardiac fibrotic response by targeting G (12/13) ????J Lipid Res http://www.kidney.de/pget.php?&tw=1&pmid=28554983 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28554983 #FOAvip English Wikipedia <ref>{{Cite pmid|28554983 }}</ref> CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induced cardiac fibrotic response by targeting G?(12/13) #MMPMID28554983 He Z ; Yang Y ; Wen Z ; Chen C ; Xu X ; Zhu Y ; Wang Y ; Wang DW J Lipid Res 2017[Jul]; 58 (7 ): 1338-1353 PMID28554983 show ga The arachidonic acid-cytochrome P450 2J2-epoxyeicosatrienoic acid (AA-CYP2J2-EET) metabolic pathway has been identified to be protective in the cardiovascular system. This study explored the effects of the AA-CYP2J2-EET metabolic pathway on cardiac fibrosis from the perspective of cardiac fibroblasts and underlying mechanisms. In in vivo studies, 8-week-old male CYP2J2 transgenic mice (aMHC-CYP2J2-Tr) and littermates were infused with angiotensin II (Ang II) or saline for 2 weeks. Results showed that CYP2J2 overexpression increased EET production. Meanwhile, impairment of cardiac function and fibrotic response were attenuated by CYP2J2 overexpression. The effects of CYP2J2 were associated with reduced activation of the ? subunits of G12 family G proteins (G?(12/13))/RhoA/Rho kinase (ROCK) cascade and elevation of the NO/cyclic guanosine monophosphate (cGMP) level in cardiac tissue. In in vitro studies, cardiac fibroblast activation, proliferation, migration, and collagen production induced by Ang II were associated with activation of the G?(12/13)/RhoA/ROCK pathway, which was inhibited by exogenous 11,12-EET. Moreover, silencing of G?(12/13) or RhoA exerted similar effects as 11,12-EET. Furthermore, inhibitory effects of 11,12-EET on G?(12/13) were blocked by NO/cGMP pathway inhibitors. Our findings indicate that enhancement of the AA-CYP2J2-EET metabolic pathway by CYP2J2 overexpression attenuates Ang II-induced cardiac dysfunction and fibrosis by reducing the fibrotic response of cardiac fibroblasts by targeting the G?(12/13)/RhoA/ROCK pathway via NO/cGMP signaling. |Angiotensin II/*pharmacology [MESH] |Animals [MESH] |Cyclic GMP/metabolism [MESH] |Cytochrome P-450 CYP2J2 [MESH] |Cytochrome P-450 Enzyme System/genetics/*metabolism [MESH] |Eicosanoids/biosynthesis/*metabolism/pharmacology [MESH] |Fibrosis [MESH] |GTP-Binding Protein alpha Subunits, G12-G13/*metabolism [MESH] |Gene Expression Regulation/drug effects [MESH] |Male [MESH] |Mice [MESH] |Myocytes, Cardiac/drug effects/*metabolism/*pathology [MESH] |Nitric Oxide/metabolism [MESH] |Organ Specificity [MESH] |Rats [MESH] |Signal Transduction/drug effects [MESH] |rho-Associated Kinases/metabolism [MESH]CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induce(epmc).pdf DeepDyve Pubget Overpricing