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10.1039/c4sc03549f http://scihub22266oqcxt.onion/10.1039/c4sc03549f C5496002!5496002 !28706648     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28706648 &cmd=llinks): Failed to open stream: HTTP request failed! 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Mesoporous silica nanoparticles for (19)F magnetic resonance imaging, fluorescence imaging, and drug delivery |pdf=|usr=}}{{28706648 }} gab.com Text Mesoporous silica nanoparticles for (19)F magnetic resonance imaging, fluorescence imaging, and drug delivery JO: Chem Sci http://www.kidney.de/pget.php?&tw=1&pmid=28706648 #FOAvip Multifunctional mesoporous silica nanoparticles (MSNs) are good candidates for multimodal applications in drug delivery, bioimaging, and cell targeting. In particular, controlled release of drugs from MSN pores constitutes one of the superior features of MSNs. In this study, a novel drug delivery carrier based on MSNs, which encapsulated highly sensitive (19)F magnetic resonance imaging (MRI) contrast agents inside MSNs, was developed. The nanoparticles were labeled with fluorescent dyes and functionalized with small molecule-based ligands for active targeting. This drug delivery system facilitated the monitoring of the biodistribution of the drug carrier by dual modal imaging (NIR/(19)F MRI). Furthermore, we demonstrated targeted drug delivery and cellular imaging by the conjugation of nanoparticles with folic acid. An anticancer drug (doxorubicin, DOX) was loaded in the pores of folate-functionalized MSNs for intracellular drug delivery. The release rates of DOX from the nanoparticles increased under acidic conditions, and were favorable for controlled drug release to cancer cells. Our results suggested that MSNs may serve as promising (19)F MRI-traceable drug carriers for application in cancer therapy and bio-imaging. Twit Text FOAVip Mesoporous silica nanoparticles for (19)F magnetic resonance imaging, fluorescence imaging, and drug delivery ????Chem Sci http://www.kidney.de/pget.php?&tw=1&pmid=28706648 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28706648 #FOAvip English Wikipedia <ref>{{Cite pmid|28706648 }}</ref> Mesoporous silica nanoparticles for (19)F magnetic resonance imaging, fluorescence imaging, and drug delivery #MMPMID28706648 Nakamura T ; Sugihara F ; Matsushita H ; Yoshioka Y ; Mizukami S ; Kikuchi K Chem Sci 2015[Mar]; 6 (3 ): 1986-1990 PMID28706648 show ga Multifunctional mesoporous silica nanoparticles (MSNs) are good candidates for multimodal applications in drug delivery, bioimaging, and cell targeting. In particular, controlled release of drugs from MSN pores constitutes one of the superior features of MSNs. In this study, a novel drug delivery carrier based on MSNs, which encapsulated highly sensitive (19)F magnetic resonance imaging (MRI) contrast agents inside MSNs, was developed. The nanoparticles were labeled with fluorescent dyes and functionalized with small molecule-based ligands for active targeting. This drug delivery system facilitated the monitoring of the biodistribution of the drug carrier by dual modal imaging (NIR/(19)F MRI). Furthermore, we demonstrated targeted drug delivery and cellular imaging by the conjugation of nanoparticles with folic acid. An anticancer drug (doxorubicin, DOX) was loaded in the pores of folate-functionalized MSNs for intracellular drug delivery. The release rates of DOX from the nanoparticles increased under acidic conditions, and were favorable for controlled drug release to cancer cells. Our results suggested that MSNs may serve as promising (19)F MRI-traceable drug carriers for application in cancer therapy and bio-imaging. äMesoporous silica nanoparticles for (19)F magnetic resonance imaging, (epmc).pdf DeepDyve Pubget Overpricing