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10.1016/j.celrep.2016.12.001 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.12.001 C5495578!5495578!28009303     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 17 (12): 3369-84 Nephropedia Template TP {{tp|p=28009303|t=2016. Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain |pdf=|usr=}}{{28009303}} gab.com Text Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28009303 #FOAvip Organoids derived from human pluripotent stem cells recapitulate the early three-dimensional organization of the human brain, but whether they establish the epigenomic and transcriptional programs essential for brain development is unknown. We compared epigenomic and regulatory features in cerebral organoids and human fetal brain, using genome-wide, base resolution DNA methylome and transcriptome sequencing. Transcriptomic dynamics in organoids faithfully modeled gene expression trajectories in early-to-mid human fetal brains. We found that early non-CG methylation accumulation at super-enhancers in both fetal brain and organoids marks forthcoming transcriptional repression in the fully developed brain. Demethylated regions (74% of 35,627) identified during organoid differentiation overlapped with fetal brain regulatory elements. Interestingly, pericentromeric repeats showed widespread demethylation in multiple types of in vitro human neural differentiation models but not in fetal brain. Our study reveals that organoids recapitulate many epigenomic features of mid-fetal human brain and also identified novel non-CG methylation signatures of brain development. Twit Text FOAVip Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28009303 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28009303 #FOAvip English Wikipedia <ref>{{Cite pmid|28009303}}</ref> Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain #MMPMID28009303 Luo C; Lancaster MA; Castanon R; Nery JR; Knoblich JA; Ecker JR Cell Rep 2016[Dec]; 17 (12): 3369-84 PMID28009303show ga Organoids derived from human pluripotent stem cells recapitulate the early three-dimensional organization of the human brain, but whether they establish the epigenomic and transcriptional programs essential for brain development is unknown. We compared epigenomic and regulatory features in cerebral organoids and human fetal brain, using genome-wide, base resolution DNA methylome and transcriptome sequencing. Transcriptomic dynamics in organoids faithfully modeled gene expression trajectories in early-to-mid human fetal brains. We found that early non-CG methylation accumulation at super-enhancers in both fetal brain and organoids marks forthcoming transcriptional repression in the fully developed brain. Demethylated regions (74% of 35,627) identified during organoid differentiation overlapped with fetal brain regulatory elements. Interestingly, pericentromeric repeats showed widespread demethylation in multiple types of in vitro human neural differentiation models but not in fetal brain. Our study reveals that organoids recapitulate many epigenomic features of mid-fetal human brain and also identified novel non-CG methylation signatures of brain development. äCerebral Organoids Recapitulate Epigenomic Signatures of the Human Fet(epmc).pdf DeepDyve Pubget Overpricing