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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Opin+Neurobiol
2016 ; 41
(ä): 53-61
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Microcircuits in respiratory rhythm generation: commonalities with other rhythm
generating networks and evolutionary perspectives
#MMPMID27589601
Ramirez JM
; Dashevskiy T
; Marlin IA
; Baertsch N
Curr Opin Neurobiol
2016[Dec]; 41
(ä): 53-61
PMID27589601
show ga
Rhythmicity is critical for the generation of rhythmic behaviors and higher brain
functions. This review discusses common mechanisms of rhythm generation,
including the role of synaptic inhibition and excitation, with a focus on the
mammalian respiratory network. This network generates three phases of breathing
and is highly integrated with brain regions associated with numerous
non-ventilatory behaviors. We hypothesize that during evolution multiple
rhythmogenic microcircuits were recruited to accommodate the generation of each
breathing phase. While these microcircuits relied primarily on excitatory
mechanisms, synaptic inhibition became increasingly important to coordinate the
different microcircuits and to integrate breathing into a rich behavioral
repertoire that links breathing to sensory processing, arousal, and emotions as
well as learning and memory.