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10.1101/cshperspect.a022186

http://scihub22266oqcxt.onion/10.1101/cshperspect.a022186
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C5495062!5495062!28108485
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suck abstract from ncbi


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pmid28108485      Cold+Spring+Harb+Perspect+Biol 2017 ; 9 (7): ä
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  • TGF-? Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation #MMPMID28108485
  • Mullen AC; Wrana JL
  • Cold Spring Harb Perspect Biol 2017[Jul]; 9 (7): ä PMID28108485show ga
  • Soon after the discovery of transforming growth factor-? (TGF-?), seminal work in vertebrate and invertebrate models revealed the TGF-? family to be central regulators of tissue morphogenesis. Members of the TGF-? family direct some of the earliest cell-fate decisions in animal development, coordinate complex organogenesis, and contribute to tissue homeostasis in the adult. Here, we focus on the role of the TGF-? family in mammalian stem-cell biology and discuss its wide and varied activities both in the regulation of pluripotency and in cell-fate commitment.
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