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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cold+Spring+Harb+Perspect+Biol 2017 ; 9 (7): ä Nephropedia Template TP
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TGF-? Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation #MMPMID28108485
Mullen AC; Wrana JL
Cold Spring Harb Perspect Biol 2017[Jul]; 9 (7): ä PMID28108485show ga
Soon after the discovery of transforming growth factor-? (TGF-?), seminal work in vertebrate and invertebrate models revealed the TGF-? family to be central regulators of tissue morphogenesis. Members of the TGF-? family direct some of the earliest cell-fate decisions in animal development, coordinate complex organogenesis, and contribute to tissue homeostasis in the adult. Here, we focus on the role of the TGF-? family in mammalian stem-cell biology and discuss its wide and varied activities both in the regulation of pluripotency and in cell-fate commitment.