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2016 ; 1
(3
): 226-237
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gab.com Text
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English Wikipedia
Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and
pancreatic cancer
#MMPMID28404095
Hart PA
; Bellin MD
; Andersen DK
; Bradley D
; Cruz-Monserrate Z
; Forsmark CE
; Goodarzi MO
; Habtezion A
; Korc M
; Kudva YC
; Pandol SJ
; Yadav D
; Chari ST
Lancet Gastroenterol Hepatol
2016[Nov]; 1
(3
): 226-237
PMID28404095
show ga
Diabetes mellitus is a group of diseases defined by persistent hyperglycaemia.
Type 2 diabetes, the most prevalent form, is characterised initially by impaired
insulin sensitivity and subsequently by an inadequate compensatory insulin
response. Diabetes can also develop as a direct consequence of other diseases,
including diseases of the exocrine pancreas. Historically, diabetes due to
diseases of the exocrine pancreas was described as pancreatogenic or
pancreatogenous diabetes mellitus, but recent literature refers to it as type 3c
diabetes. It is important to note that type 3c diabetes is not a single entity;
it occurs because of a variety of exocrine pancreatic diseases with varying
mechanisms of hyperglycaemia. The most commonly identified causes of type 3c
diabetes are chronic pancreatitis, pancreatic ductal adenocarcinoma,
haemochromatosis, cystic fibrosis, and previous pancreatic surgery. In this
Review, we discuss the epidemiology, pathogenesis, and clinical relevance of type
3c diabetes secondary to chronic pancreatitis and pancreatic ductal
adenocarcinoma, and highlight several important knowledge gaps.