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10.1016/j.tibtech.2017.04.002 http://scihub22266oqcxt.onion/10.1016/j.tibtech.2017.04.002 C5495001!5495001!28552428     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Biotechnol 2017 ; 35 (7): 625-39 Nephropedia Template TP {{tp|p=28552428|t=2017. Optogenetic approaches to drug discovery in neuroscience and beyond |pdf=|usr=}}{{28552428}} gab.com Text Optogenetic approaches to drug discovery in neuroscience and beyond JO: Trends Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=28552428 #FOAvip Recent advances in optogenetics have opened new routes to drug discovery, particularly in neuroscience. Physiological cellular assays probe functional phenotypes that connect genomic data to patient health. Optogenetic tools, and in particular tools for all-optical electrophysiology, now provide means to probe cellular disease models with unprecedented throughput and information content. These techniques promise to identify functional phenotypes associated with disease states and to identify compounds that improve cellular function regardless of whether the compound acts directly on a target or through a bypass mechanism. This review discusses opportunities and unresolved challenges in applying optogenetic techniques throughout the discovery pipeline, from target identification and validation, to target-based and phenotypic screens, to clinical trials. Twit Text FOAVip Optogenetic approaches to drug discovery in neuroscience and beyond ????Trends Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=28552428 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28552428 #FOAvip English Wikipedia <ref>{{Cite pmid|28552428}}</ref> Optogenetic approaches to drug discovery in neuroscience and beyond #MMPMID28552428 Zhang H; Cohen AE Trends Biotechnol 2017[Jul]; 35 (7): 625-39 PMID28552428show ga Recent advances in optogenetics have opened new routes to drug discovery, particularly in neuroscience. Physiological cellular assays probe functional phenotypes that connect genomic data to patient health. Optogenetic tools, and in particular tools for all-optical electrophysiology, now provide means to probe cellular disease models with unprecedented throughput and information content. These techniques promise to identify functional phenotypes associated with disease states and to identify compounds that improve cellular function regardless of whether the compound acts directly on a target or through a bypass mechanism. This review discusses opportunities and unresolved challenges in applying optogenetic techniques throughout the discovery pipeline, from target identification and validation, to target-based and phenotypic screens, to clinical trials. äOptogenetic approaches to drug discovery in neuroscience and beyond (epmc).pdf DeepDyve Pubget Overpricing