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10.1038/ncb3537 http://scihub22266oqcxt.onion/10.1038/ncb3537 C5494977!5494977!28553939     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Cell+Biol 2017 ; 19 (6): 724-31 Nephropedia Template TP {{tp|p=28553939|t=2017. Linking E-cadherin mechanotransduction to cell metabolism through force mediated activation of AMPK |pdf=|usr=}}{{28553939}} gab.com Text Linking E-cadherin mechanotransduction to cell metabolism through force mediated activation of AMPK JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28553939 #FOAvip The response of cells to mechanical force is a major determinant of cell behavior and is an energetically costly event. How cells derive energy to resist mechanical force is unknown. Here, we show that application of force to E-cadherin stimulates Liver Kinase B1 (LKB1) to activate AMP-activated protein kinase (AMPK), a master regulator of energy homeostasis. LKB1 recruits AMPK to the E-cadherin mechanotransduction complex, thereby stimulating actomyosin contractility, glucose uptake, and ATP production. The increase in ATP provides energy to reinforce the adhesion complex and actin cytoskeleton so the cell can resist physiological forces. Together, these findings reveal a paradigm for how mechanotransduction and metabolism are linked and provide a framework for understanding how diseases involving contractile and metabolic disturbances arise. Twit Text FOAVip Linking E-cadherin mechanotransduction to cell metabolism through force mediated activation of AMPK ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28553939 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28553939 #FOAvip English Wikipedia <ref>{{Cite pmid|28553939}}</ref> Linking E-cadherin mechanotransduction to cell metabolism through force mediated activation of AMPK #MMPMID28553939 Bays JL; Campbell HK; Heidema C; Sebbagh M; DeMali KA Nat Cell Biol 2017[Jun]; 19 (6): 724-31 PMID28553939show ga The response of cells to mechanical force is a major determinant of cell behavior and is an energetically costly event. How cells derive energy to resist mechanical force is unknown. Here, we show that application of force to E-cadherin stimulates Liver Kinase B1 (LKB1) to activate AMP-activated protein kinase (AMPK), a master regulator of energy homeostasis. LKB1 recruits AMPK to the E-cadherin mechanotransduction complex, thereby stimulating actomyosin contractility, glucose uptake, and ATP production. The increase in ATP provides energy to reinforce the adhesion complex and actin cytoskeleton so the cell can resist physiological forces. Together, these findings reveal a paradigm for how mechanotransduction and metabolism are linked and provide a framework for understanding how diseases involving contractile and metabolic disturbances arise. äLinking E-cadherin mechanotransduction to cell metabolism through forc(epmc).pdf DeepDyve Pubget Overpricing