Ultrasound-guided drug delivery in cancer #MMPMID28607323
Mullick Chowdhury S; Lee T; Willmann JK
Ultrasonography 2017[Jul]; 36 (3): 171-84 PMID28607323show ga
Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery technology has shown that this approach can improve spatially confined delivery of drugs and genes to target tissues while reducing systemic dose and toxicity. The mechanism behind enhanced delivery of therapeutics is sonoporation, the formation of openings in the vasculature, induced by ultrasound-triggered oscillations and destruction of microbubbles. In this review, progress and challenges of USMB mediated drug delivery are summarized, with special focus on cancer therapy.