Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28693179
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Oncol+Lett
2017 ; 14
(1
): 376-382
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Association between periostin and epithelial-mesenchymal transition in esophageal
squamous cell carcinoma and its clinical significance
#MMPMID28693179
Lv YJ
; Wang W
; Ji CS
; Jia
; Xie MR
; Hu B
Oncol Lett
2017[Jul]; 14
(1
): 376-382
PMID28693179
show ga
The present study aimed to investigate the association between periostin (POSTN),
epithelial cadherin (E-cad) and vimentin (Vim) expression levels in esophageal
squamous cell carcinoma (ESCC) tissues, and its clinicopathological significance.
A total of 58 patients with esophageal cancer were enrolled. Immunohistochemistry
was performed to quantify the expression levels of POSTN, E-cad and Vim. E-cad
expression was reduced in ESCC tissue, which was associated with severe tumor
node metastasis (TNM) stage (P<0.001), lymphatic metastasis (P<0.001) and
vascular invasion (P=0.026). Conversely, Vim expression was found to be increased
in ESCC tissues, and had associations with TNM stage (P=0.039) and lymphatic
metastasis (P=0.039). POSTN overexpression observed in ESCC cells was associated
with attenuation of E-cad expression (P<0.001) and elevated expression levels of
Vim (P<0.001). Additionally, significant correlations between the overexpression
of POSTN in ESCC cells and clinicopathological variables including TNM staging
(P=0.009), degree of differentiation (P<0.001), lymphatic metastasis (P=0.009)
and vascular invasion (P=0.002) were verified. Multivariate analysis revealed
that overexpression of POSTN in ESCC cancer cells is able to predict the poor
prognosis of patients independently of overall survival (P=0.022) and disease
free survival (P=0.019). The preliminary findings of the present study
demonstrate that POSTN is involved in the epithelial-mesenchymal transition of
ESCC cells, and may therefore be a predictive factor for tumor invasion and
metastasis, as well as an indicator of poor prognosis for patients with ESCC.
free
free
free
