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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Syst+Rev
2017 ; 6
(1
): 123
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A systematic review of the processes used to link clinical trial registrations to
their published results
#MMPMID28669351
Bashir R
; Bourgeois FT
; Dunn AG
Syst Rev
2017[Jul]; 6
(1
): 123
PMID28669351
show ga
BACKGROUND: Studies measuring the completeness and consistency of trial
registration and reporting rely on linking registries with bibliographic
databases. In this systematic review, we quantified the processes used to
identify these links. METHODS: PubMed and Embase databases were searched from
inception to May 2016 for studies linking trial registries with bibliographic
databases. The processes used to establish these links were categorised as
automatic when the registration identifier was available in the bibliographic
database or publication, or manual when linkage required inference or contacting
of trial investigators. The number of links identified by each process was
extracted where available. Linear regression was used to determine whether the
proportions of links available via automatic processes had increased over time.
RESULTS: In 43 studies that examined cohorts of registry entries, 24 used
automatic and manual processes to find articles; 3 only automatic; and 11 only
manual (5 did not specify). Twelve studies reported results for both manual and
automatic processes and showed that a median of 23% (range from 13 to 42%)
included automatic links to articles, while 17% (range from 5 to 42%) of registry
entries required manual processes to find articles. There was no evidence that
the proportion of registry entries with automatic links had increased (R
(2)?=?0.02, p?=?0.36). In 39 studies that examined cohorts of articles, 21 used
automatic and manual processes; 9 only automatic; and 2 only manual (7 did not
specify). Sixteen studies reported numbers for automatic and manual processes and
indicated that a median of 49% (range from 8 to 97%) of articles had automatic
links to registry entries, and 10% (range from 0 to 28%) required manual
processes to find registry entries. There was no evidence that the proportion of
articles with automatic links to registry entries had increased (R (2)?=?0.01,
p?=?0.73). CONCLUSIONS: The linkage of trial registries to their corresponding
publications continues to require extensive manual processes. We did not find
that the use of automatic linkage has increased over time. Further investigation
is needed to inform approaches that will ensure publications are properly linked
to trial registrations, thus enabling efficient monitoring of trial reporting.