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2017 ; 17
(1
): 459
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Report of an unsual case of anophthalmia and craniofacial cleft in a newborn with
Toxoplasma gondii congenital infection
#MMPMID28673238
Arce-Estrada GE
; Gómez-Toscano V
; Cedillo-Peláez C
; Sesman-Bernal AL
; Bosch-Canto V
; Mayorga-Butrón JL
; Vargas-Villavicencio JA
; Correa D
BMC Infect Dis
2017[Jul]; 17
(1
): 459
PMID28673238
show ga
BACKGROUND: We present one unusual case of anophthalmia and craniofacial cleft,
probably due to congenital toxoplasmosis only. CASE PRESENTATION: A two-month-old
male had a twin in utero who disappeared between the 7(th) and the 14(th) week of
gestation. At birth, the baby presented anophthalmia and craniofacial cleft, and
no sign compatible with genetic or exposition/deficiency problems, like the
Wolf-Hirschhorn syndrome or maternal vitamin A deficiency. Congenital
toxoplasmosis was confirmed by the presence of IgM abs and IgG neo-antibodies in
western blot, as well as by real time PCR in blood. CMV infection was also
discarded by PCR and IgM negative results. Structures suggestive of T. gondii
pseudocysts were observed in a biopsy taken during the first functional/esthetic
surgery. CONCLUSIONS: We conclude that this is a rare case of anophthalmia
combined with craniofacial cleft due to congenital toxoplasmosis, that must be
considered by physicians. This has not been reported before.