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10.15252/embr.201744072 http://scihub22266oqcxt.onion/10.15252/embr.201744072 C5494534!5494534!28487352     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Rep 2017 ; 18 (7): 1090-9 Nephropedia Template TP {{tp|p=28487352|t=2017. In vivo structures of an intact type VI secretion system revealed by electron cryotomography |pdf=|usr=}}{{28487352}} gab.com Text In vivo structures of an intact type VI secretion system revealed by electron cryotomography JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=28487352 #FOAvip The type VI secretion system (T6SS) is a versatile molecular weapon used by many bacteria against eukaryotic hosts or prokaryotic competitors. It consists of a cytoplasmic bacteriophage tail?like structure anchored in the bacterial cell envelope via a cytoplasmic baseplate and a periplasmic membrane complex. Rapid contraction of the sheath in the bacteriophage tail?like structure propels an inner tube/spike complex through the target cell envelope to deliver effectors. While structures of purified contracted sheath and purified membrane complex have been solved, because sheaths contract upon cell lysis and purification, no structure is available for the extended sheath. Structural information about the baseplate is also lacking. Here, we use electron cryotomography to directly visualize intact T6SS structures inside Myxococcus xanthus cells. Using sub?tomogram averaging, we resolve the structure of the extended sheath and membrane?associated components including the baseplate. Moreover, we identify novel extracellular bacteriophage tail fiber?like antennae. These results provide new structural insights into how the extended sheath prevents premature disassembly and how this sophisticated machine may recognize targets. Twit Text FOAVip In vivo structures of an intact type VI secretion system revealed by electron cryotomography ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=28487352 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28487352 #FOAvip English Wikipedia <ref>{{Cite pmid|28487352}}</ref> In vivo structures of an intact type VI secretion system revealed by electron cryotomography #MMPMID28487352 Chang Y; Rettberg LA; Ortega DR; Jensen GJ EMBO Rep 2017[Jul]; 18 (7): 1090-9 PMID28487352show ga The type VI secretion system (T6SS) is a versatile molecular weapon used by many bacteria against eukaryotic hosts or prokaryotic competitors. It consists of a cytoplasmic bacteriophage tail?like structure anchored in the bacterial cell envelope via a cytoplasmic baseplate and a periplasmic membrane complex. Rapid contraction of the sheath in the bacteriophage tail?like structure propels an inner tube/spike complex through the target cell envelope to deliver effectors. While structures of purified contracted sheath and purified membrane complex have been solved, because sheaths contract upon cell lysis and purification, no structure is available for the extended sheath. Structural information about the baseplate is also lacking. Here, we use electron cryotomography to directly visualize intact T6SS structures inside Myxococcus xanthus cells. Using sub?tomogram averaging, we resolve the structure of the extended sheath and membrane?associated components including the baseplate. Moreover, we identify novel extracellular bacteriophage tail fiber?like antennae. These results provide new structural insights into how the extended sheath prevents premature disassembly and how this sophisticated machine may recognize targets. äIn vivo structures of an intact type VI secretion system revealed by e(epmc).pdf DeepDyve Pubget Overpricing