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2017 ; 7
(7
): 1009-1016
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Silencing of FABP1 ameliorates hepatic steatosis, inflammation, and oxidative
stress in mice with nonalcoholic fatty liver disease
#MMPMID28680813
Mukai T
; Egawa M
; Takeuchi T
; Yamashita H
; Kusudo T
FEBS Open Bio
2017[Jul]; 7
(7
): 1009-1016
PMID28680813
show ga
Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence worldwide
and has been identified as a risk factor for cirrhosis and hepatocellular
carcinoma. However, there is no effective pharmacologic treatment for NAFLD.
FABP1 is a liver-specific fatty acid-binding protein (FABP) that plays important
roles in intracellular lipid metabolism in the liver. We investigated the effect
of repression of FABP1 expression on NAFLD, using adenovirus-mediated silencing
of FABP1. FABP1 knockdown in the liver decreased the liver weight and hepatic
triglyceride (TG) accumulation. The expression of inflammatory and oxidative
stress markers in the liver was also reduced. The level of thiobarbituric
acid-reactive substances, a marker of lipid peroxidation, in the liver of FABP1
knockdown mice was significantly decreased. These results suggest that FABP1
reduction in the liver is an effective approach against NAFLD.