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10.1126/science.aah4043 http://scihub22266oqcxt.onion/10.1126/science.aah4043 C5493203!5493203!28104891     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2017 ; 355 (6322): 294-8 Nephropedia Template TP {{tp|p=28104891|t=2017. Protein Structure Determination using Metagenome sequence data |pdf=|usr=}}{{28104891}} gab.com Text Protein Structure Determination using Metagenome sequence data JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=28104891 #FOAvip Despite decades of work by structural biologists, there are still ~5200 protein families with unknown structure outside the range of comparative modeling. We show that Rosetta structure prediction guided by residue-residue contacts inferred from evolutionary information can accurately model proteins that belong to large families, and that metagenome sequence data more than triples the number of protein families with sufficient sequences for accurate modeling. We then integrate metagenome data, contact based structure matching and Rosetta structure calculations to generate models for 614 protein families with currently unknown structures; 206 are membrane proteins and 137 have folds not represented in the PDB. This approach provides the representative models for large protein families originally envisioned as the goal of the protein structure initiative at a fraction of the cost. Twit Text FOAVip Protein Structure Determination using Metagenome sequence data ????Science http://www.kidney.de/pget.php?&tw=1&pmid=28104891 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28104891 #FOAvip English Wikipedia <ref>{{Cite pmid|28104891}}</ref> Protein Structure Determination using Metagenome sequence data #MMPMID28104891 Ovchinnikov S; Park H; Varghese N; Huang PS; Pavlopoulos GA; Kim DE; Kamisetty H; Kyrpides NC; Baker D Science 2017[Jan]; 355 (6322): 294-8 PMID28104891show ga Despite decades of work by structural biologists, there are still ~5200 protein families with unknown structure outside the range of comparative modeling. We show that Rosetta structure prediction guided by residue-residue contacts inferred from evolutionary information can accurately model proteins that belong to large families, and that metagenome sequence data more than triples the number of protein families with sufficient sequences for accurate modeling. We then integrate metagenome data, contact based structure matching and Rosetta structure calculations to generate models for 614 protein families with currently unknown structures; 206 are membrane proteins and 137 have folds not represented in the PDB. This approach provides the representative models for large protein families originally envisioned as the goal of the protein structure initiative at a fraction of the cost. äProtein Structure Determination using Metagenome sequence data (epmc).pdf DeepDyve Pubget Overpricing