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10.1016/j.devcel.2017.04.014 http://scihub22266oqcxt.onion/10.1016/j.devcel.2017.04.014 C5492999!5492999!28535372     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dev+Cell 2017 ; 41 (4): 366-381.e4 Nephropedia Template TP {{tp|p=28535372|t=2017. A brain region-specific neural pathway regulating germinal matrix angiogenesis |pdf=|usr=}}{{28535372}} gab.com Text A brain region-specific neural pathway regulating germinal matrix angiogenesis JO: Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=28535372 #FOAvip Intimate communication between neural and vascular cells is critical for normal brain development and function. Germinal matrix (GM), a key primordium for the brain reward circuitry, is unique among brain regions for its distinct pace of angiogenesis and selective vulnerability to hemorrhage during development. A major neonatal condition, GM hemorrhage can lead to cerebral palsy, hydrocephalus, and mental retardation. Here we identify a brain region-specific neural progenitor-based signaling pathway dedicated to regulating GM vessel development. This pathway consists of cell surface sphingosine-1-phosphate receptors, an intracellular cascade including G? co-factor Ric8a and p38 MAPK, and target gene integrin ?8, which in turn regulates vascular TGF? signaling. These findings provide novel insights into region-specific specialization of neurovascular communication, with special implications for deciphering potent early-life endocrine as well as potential gut microbiota impacts on brain reward circuitry. They also identify tissue-specific molecular targets for GM hemorrhage intervention. Twit Text FOAVip A brain region-specific neural pathway regulating germinal matrix angiogenesis ????Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=28535372 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28535372 #FOAvip English Wikipedia <ref>{{Cite pmid|28535372}}</ref> A brain region-specific neural pathway regulating germinal matrix angiogenesis #MMPMID28535372 Ma S; Santhosh D; Peeyush Kumar T; Huang Z Dev Cell 2017[May]; 41 (4): 366-381.e4 PMID28535372show ga Intimate communication between neural and vascular cells is critical for normal brain development and function. Germinal matrix (GM), a key primordium for the brain reward circuitry, is unique among brain regions for its distinct pace of angiogenesis and selective vulnerability to hemorrhage during development. A major neonatal condition, GM hemorrhage can lead to cerebral palsy, hydrocephalus, and mental retardation. Here we identify a brain region-specific neural progenitor-based signaling pathway dedicated to regulating GM vessel development. This pathway consists of cell surface sphingosine-1-phosphate receptors, an intracellular cascade including G? co-factor Ric8a and p38 MAPK, and target gene integrin ?8, which in turn regulates vascular TGF? signaling. These findings provide novel insights into region-specific specialization of neurovascular communication, with special implications for deciphering potent early-life endocrine as well as potential gut microbiota impacts on brain reward circuitry. They also identify tissue-specific molecular targets for GM hemorrhage intervention. äA brain region-specific neural pathway regulating germinal matrix angi(epmc).pdf DeepDyve Pubget Overpricing