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10.1016/j.tibtech.2017.03.014 http://scihub22266oqcxt.onion/10.1016/j.tibtech.2017.03.014 C5492987!5492987!28438340     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Biotechnol 2017 ; 35 (7): 653-64 Nephropedia Template TP {{tp|p=28438340|t=2017. Applications of pHLIP Technology for Cancer Imaging and Therapy |pdf=|usr=}}{{28438340}} gab.com Text Applications of pHLIP Technology for Cancer Imaging and Therapy JO: Trends Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=28438340 #FOAvip Acidity is a biomarker of cancer that is not subject to the blunting clonal selection effects that reduce the efficacy of other biomarker technologies, like antibody targeting. The pH (Low) Insertion Peptides (pHLIPs) provide new opportunities for targeting acidic tissues. Through the physical mechanism of membrane-associated folding, pHLIPs are triggered by the acidic microenvironment to insert and span the membranes of tumor cells. The pHLIP platform can be applied to imaging acidic tissues, delivering cell-permeable and impermeable molecules to the cytoplasm, and promoting the cellular uptake of nanoparticles. Since acidosis is a hallmark of tumor development, progression, and aggressiveness, the pHLIP technology may prove useful in targeting cancer cells and metastases for tumor diagnosis, imaging, and therapy. Twit Text FOAVip Applications of pHLIP Technology for Cancer Imaging and Therapy ????Trends Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=28438340 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28438340 #FOAvip English Wikipedia <ref>{{Cite pmid|28438340}}</ref> Applications of pHLIP Technology for Cancer Imaging and Therapy #MMPMID28438340 Wyatt LC; Lewis JS; Andreev OA; Reshetnyak YK; Engelman DM Trends Biotechnol 2017[Jul]; 35 (7): 653-64 PMID28438340show ga Acidity is a biomarker of cancer that is not subject to the blunting clonal selection effects that reduce the efficacy of other biomarker technologies, like antibody targeting. The pH (Low) Insertion Peptides (pHLIPs) provide new opportunities for targeting acidic tissues. Through the physical mechanism of membrane-associated folding, pHLIPs are triggered by the acidic microenvironment to insert and span the membranes of tumor cells. The pHLIP platform can be applied to imaging acidic tissues, delivering cell-permeable and impermeable molecules to the cytoplasm, and promoting the cellular uptake of nanoparticles. Since acidosis is a hallmark of tumor development, progression, and aggressiveness, the pHLIP technology may prove useful in targeting cancer cells and metastases for tumor diagnosis, imaging, and therapy. äApplications of pHLIP Technology for Cancer Imaging and Therapy (epmc).pdf DeepDyve Pubget Overpricing